Abstract
Different antioxidants and free radical scavengers on aflatoxin production are analysed. The different compounds at different concentration were used: buthylated hydroxyanisole (BHA), buthylated hydroxytoluene (BHT), α-tocopherol (vitamin E), ascorbic acid (vitamin C), reduced glutathione, cysteine, cysteamine. The above compounds were tested in culture ofAspergillus parasiticus supplemented with carbon tetrachloride, a potent stimulating agent of aflatoxin biosynthesis.
Cysteamine and BHA highly inhibited the aflatoxin production induced by carbon tetrachloride, the inhibition decreased by lowering the concentration.
On the contrary, vitamin E, vitamin C, reduced glutathione and cysteine further enhanced the carbon tetrachloride stimulating effect. The addition of the above compounds did not significantly affect the growth of the fungal mycelia.
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References
Fabbri AA, Fanelli C and Serafini M (1980) Aflatoxin production on cereals, oil seeds and some organic fractions extracted from sunflower. Rendiconti Atti Academia Nazionale delle Scienze (detta dei XL) 98(IV):219–228
Fabbri AA, Fanelli C, Panfili G, Passi S and Fasella P (1983) Lipoperoxidation and aflatoxin biosynthesis by Aspergillus parasiticus and A. flavus. J Gen Microbiol 129:3447–3452
Fanelli C, Fabbri AA, Finotti E and Passi S (1983) Stimulation of aflatoxin biosynthesis by lipophilic epoxides. J Gen Microbiol 129:1721–1723
Fanelli C, Fabbri AA, Passi S and Fasella P (1983) Control mechanisms of aflatoxin biosynthesis. Mycotoxin Symposium in Sydney 12-15/8/83 abstP9
Fanelli C, Fabbri AA, Finotti E, Fasella P and Passi S (1984) Free radicals and aflatoxin biosynthesis. Experientia 40:191–193
Passi S, Fanelli C, Fabbri AA, Finotti E, Panfili G and Nazzaro-Porro M (1985) Effect of halomethanes on aflatoxin induction in cultures of Aspergillus parasiticus. J Gen Microbiol 131:687–691
Fanelli C, Fabbri AA and Passi S (1980) Growth requirements and lipid metabolism of Aspergillus flavus. Trans Brit Mycological Soc 75:371–375
Fanelli C, Fabbri AA, Finotti E, Panfili G and Passi S (1983) Cerulenin and tetrahydrocerulenin: stimulating factors of aflatoxin biosynthesis. Trans Brit Mycological Soc 81:201–204
Recknagel RO, Glende Jr, EA and Hruszewycz AM (1977) Chemical mechanism in carbon tetrachloride toxicity. In “Free radical in Biology”, Vol III, Pryor WA (Ed), Academic Press Inc, New York, pp 97–132
Reynolds ES and Treinen Moslen M (1980) Free radicals damage in liver. In “Free radical in Biology”, Vol IV, Pryor WA (Ed), Academic Press Inc, New York, pp 49–94
Kosower NS and Kosower EM (1976) The glutathione-glutathionedisulfide system. In “Free radical in Biology”, Vol II, Pryor WA (Ed), Academic Press Inc, New York, pp 55–84
Bielski BHJ and Gebicki JM (1977) Application of radiation chemistry to Biology. In “Free radical in Biology”, Vol III, Pryor WA (Ed), Academic Press Inc, New York, pp 1–51
Swartz HM and Dodd JF (1981) The role of ascorbic acid on radical reactions in vivo. In “Oxygen and Oxy-radicals in Chemistry and Biology”. Rodgers MAJ and Powers EL (Eds), Academic Press Inc, New York, pp 109–118
Witting LA (1980) Vitamin E and lipid antioxidants in free radical-initiated reactions. In “Free radical in Biology”, Vol IV, Pryor WA (Ed), Academic Press Inc, New York, pp 295–319
Simic MG (1981) Vitamin E Radicals. In “Oxygen and Oxy-radicals in Chemistry and Biology”. Rodgers MAJ and Powers EL (Eds), Academic Press Inc, New York, pp 109–118
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Fanelli, C., Fabbri, A.A., Pieretti, S. et al. Effect of different antioxidants and free radical scavengers on aflatoxin production. Mycotox Res 1, 65–69 (1985). https://doi.org/10.1007/BF03192005
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DOI: https://doi.org/10.1007/BF03192005