Skip to main content
SpringerLink
Log in

Influence of pregnancy on one-compartmental bio-metric blood loss calculations after cesarean section and gynaecological surgery

  • Published:
European Journal of Drug Metabolism and Pharmacokinetics Aims and scope Submit manuscript

Summary

To date there are no data in the literature on the procedure for the indirect measurement of blood loss during cesarean section, based on the post-operative drop in haemoglobin (Hb), which has been due to the lack of biometrically determined parameters for the calculation of blood volume in pregnant women. This study was therefore conducted to determine the applicability of the drop in Hb levels blood loss calculation during cesarean section, based on a model previously validated in non-pregnant women. We compared this procedure in 54 patients who underwent cesarean section and 12 non-pregnant patients subjected to gynaecological surgery. The coefficient of the regression slope for the blood volume collected during surgery and the calculated blood loss in pregnant (y=0.6286x+366) and non-pregnant patients (y=0.7605x+514) did not show any significant difference (t=1.1009, p>0.5, 95% confidence interval:−2.736, +2.473). Our study therefore demonstrated the applicability of the procedure for the indirect measurement of surgical blood loss both in pregnant and non-pregnant women.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Markantonis S.L., Kostopanagiotou G., Panidis D., Smirniotis V., Voros D. (2004) Effects of blood loss and fluid volume replacement on serum and tissue gentamycin concentrations during colorectal surgery. Clin. Ther., 26, 271–281.

    Article  CAS  PubMed  Google Scholar 

  2. Flordal P.A., Neander G. (1991) Blood loss in total hip replacement. Arch. Orthop. Trauma. Surg., Ill, 34–38.

    Article  Google Scholar 

  3. Flordal P.A. (1997) Measurement of blood loss in clinical studies. Eur. J. Anaesthesiol., 14 (Suppl 14), 35–37.

    Article  CAS  Google Scholar 

  4. Allen T.H., Peng M.X., Chen K.P., Huang T.F., Chang C., Fang H.S. (1956) Prediction of blood volume and adiposity in man from body weight and cube of height. Metabolism, 5, 328–345.

    CAS  PubMed  Google Scholar 

  5. Nadler S.B., Hidalgo J.U., Bloch T. (1962) Prediction of blood volume in normal human adults. Surgery, 51, 224–232.

    Google Scholar 

  6. Lagneau F., Marty J., Beyne P., Tod M. (2005) Physiological modeling for indirectevaluation of drugtissular pharmacokinetics under non-steady-state conditions: an example of antimicrobial prophylaxis during liver surgery. J. Pharmacokin. Pharmacodyn. 32, 1–32.

    Article  CAS  Google Scholar 

  7. Bauer L.A., Horn J.R., Maxon M.S., Easterling T.R., Shon D.D., Strandness D.E. (2000) Effect of metoprolol and verapamil administered separately and concurrently after single doses on liver blood flow and drug disposition. J. Clin. Pharmacol., 40, 533–543.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gynecology and Obstetrics, Faculty of Medicine, University Hospital of Novi Sad, Novi Sad, Republic of Serbia

    Zorica Grujić

  2. Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, Hajduk Veljkova 3, 21000, Novi Sad, Republic of Serbia

    Jovan Popović

Authors
  1. Jovan Popović
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zorica Grujić
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Popović, J., Grujić, Z. Influence of pregnancy on one-compartmental bio-metric blood loss calculations after cesarean section and gynaecological surgery. Eur. J. Drug Metabol. Pharmacokinet. 33, 53–59 (2008). https://doi.org/10.1007/BF03191019

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03191019

Key words

Search

Navigation