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Atrial natriuretic peptide contributes to the antihypertensive action of many drugs

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Summary

Data derived from a 10 years research program of our team demonstrate that many categories of antihypertensive drugs like β-adrenergic blockers, α1-adrenergic blockers, ACE inhibitors, AT1-receptor antagonists and calcium-entry blockers increase plasma atrial natriuretic peptide (ANP) levels after a medium- term treatment of patients suffering from moderate essential hypertension. ANP always increases despite the drop of the arterial pressure and the fact that the left atrial and ventricular diameters remain unchanged or slightly reduced. These findings indicate that the increase of ANP plasma levels is not the result of a mechanical overload in the left cardiac chambers but the result of a pharmacological action. In conclusion, ANP is a universal factor contributing to the antihypertensive action of many drugs.

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Authors and Affiliations

  1. Department of 2nd Cardiology, Medical School of Aristotle University of Thessaloniki, Greece

    C. L. Papadopoulos

  2. Department of Pharmacology, Medical School of Aristole University of Thessaloniki, 3 Vogatsikou st., 54622, Thessaloniki, Greece

    B. A. Kokkas M.D, Ph.D.

Authors
  1. C. L. Papadopoulos
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  2. B. A. Kokkas M.D, Ph.D.
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Papadopoulos, C.L., Kokkas, B.A. Atrial natriuretic peptide contributes to the antihypertensive action of many drugs. Eur. J. Drug Metab. Pharmacokinet. 28, 55–57 (2003). https://doi.org/10.1007/BF03190867

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  • DOI: https://doi.org/10.1007/BF03190867

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