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Pharmacokinetics and bioavailability of acyclovir sustained-release tablets in dogs

European Journal of Drug Metabolism and Pharmacokinetics volume 31, pages 17–20 (2006)Cite this article

Summary

The pharmacokinetics and bioavailability of acyclovir sustained-release tablets in dogs were investigated. Blood concentrations of acyclovir were determined by RP-HPLC after a single oral dose of two kinds of acyclovir tablets given separately to 6 beagle dogs. The main pharmacokinetics parameters of the acyclovir sustained-release tablet were as follows: T1/2, Tmax and Cmax were 4.10±0.20 h, 4.05±0.54 h and 6.90±0.68 μg-ml−1, respectively. MRT was 9.02±0.44 h. Using acyclovir standard tablet as control, relative bioavailability of the acyclovir sustained-release tablet was 152.2±49.90 %. According to the two-tailed f-test, there was a distinct difference in the data for Tmax, Cmax and AUC between acyclovir sustained-release tablets and acyclovir standard tablets, and the absorbability of acyclovir sustained-release tablets was much better than that of the acyclovir standard tablets.

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Affiliations

  1. Department of Pharmacy, Nanjing Medical University, 210029, Nanjing, Jiangsu, People’s Republic of China

    Qing Yang & Qin Hu

Authors
  1. Qing Yang
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  2. Qin Hu
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Yang, Q., Hu, Q. Pharmacokinetics and bioavailability of acyclovir sustained-release tablets in dogs. European Journal of Drug Metabolism and Pharmacokinetics 31, 17–20 (2006). https://doi.org/10.1007/BF03190637

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  • DOI: https://doi.org/10.1007/BF03190637

Keywords

  • Acyclovir
  • pharmacokinetics
  • bioavailability
  • HPLC