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Comparative effect of different types of food on the bioavailability of cefaclor extended release tablet

Summary

This randomized, six-treatment, six-period, six sequence, single dose, crossover pharmacokinetic study assessed the effect of different types of food on the bioavailability of 500-mg cefaclor extended release tablet in 23 healthy male volunteers. A single dose of cefaclor extended release 500-mg tablet was administered at six occasions: after overnight fasting, after two vegetarian (high-fat and low-fat), two non-vegetarian (high-fat and low-fat) and rice diets. Serial blood samples were collected up to 12 h after dose. Serum cefaclor concentrations were determined by a validated HPLC method. An almost equivalent increase in both Cmax and AUC was observed with both high-fat non-vegetarian and low-fat vegetarian breakfasts. However, when MIC90 values, a pharmacodynamic end-point were compared, the low-fat vegetarian diet fared better than the high-fat non-vegetarian diet. The results obtained favor low-fat vegetarian diet (breakfast) to be taken with cefaclor extended release tablet to achieve maximum benefit in terms of clinical efficacy.

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Correspondence to P. L. Sharma MD, Ph.D..

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Khan, B.A.H., Ahmed, T., Karim, S. et al. Comparative effect of different types of food on the bioavailability of cefaclor extended release tablet. European Journal of Drug Metabolism and Pharmacokinetics 29, 125–132 (2004). https://doi.org/10.1007/BF03190587

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Keywords

  • Cefaclor extended release
  • food effect
  • bioavailability
  • pharmacokinetics