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Absorption of ethyl 2-cyanoacrylate tissue adhesive

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Summary

The aim of this study was to investigate absorption of ethyl 2-cyanoacrylate glue when used as a tissue adhesive. Ethyl 2-cyanoacrylate was applied subcutaneously to four rats; its presence in blood and urine was investigated by using High Pressure Liquid Chromatography. Blood samples were drawn at baseline and after 2, 4, 6, 24, 48, 54, 78, 96 hours following application. Urine samples were obtained at baseline and after 4, 24, 48, 72, 96 hours. Administration of ethyl 2-cyanoacrylate resulted in its absorption of unchanged ethyl 2-cyanoacrylate and unknown metabolites, in plasma and urine.

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey

    Mehmet Kaplan, Mustafa Sinan Kut & Mahmut Murat Demirtas

  2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, 81010, Istanbul, Turkey

    Basak Oral & Sevim Rollas

Authors
  1. Mehmet Kaplan
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  2. Basak Oral
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  3. Sevim Rollas
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  4. Mustafa Sinan Kut
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  5. Mahmut Murat Demirtas
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Kaplan, M., Oral, B., Rollas, S. et al. Absorption of ethyl 2-cyanoacrylate tissue adhesive. European Journal of Drug Metabolism and Pharmacokinetics 29, 77–81 (2004). https://doi.org/10.1007/BF03190579

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  • DOI: https://doi.org/10.1007/BF03190579

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