Summary
This study compared some pharmacokinetic parameters of DL-lysine-acetyl salicylate administered intravenously (i.v.) and intramuscularly (i.m.) at a dose of 20 mg/kg in camels, sheep and goats. The data was analyzed using a non-compartmental model. In camels, sheep and goats given the drug i.v., the t1/2 values were 43.1, 31.2 and 27.3; the clearance (CI) values were 203.7, 261.1, and 280.4 ml/h/kg, while the area under the curve (AUC) were 100.1, 106.9 and 110.5 mg.h/L, respectively. In camels, sheep and goats given the drug by the i.m. route the mean peak plasma concentration (Cmax) were 0.94, 1.44 and 1.74 mg/ml, and the time to reach Cmax (tmax) were 2.94, 2.57 and 2.43h, respectively. The t1/2 values were 48.9, 38.2 and 36.0 min; the clearance (CI) values were 261.3, 297.4 and 306.4 ml/h/kg, while the area under the curve (AUC) were 101.6, 117.3 and 123.7 mg.h/L, respectively. The drug bioavailability (F) in camels, sheep and goats were 71.3, 78.4 and 79.4% respectively. These findings suggest that the rate of absorption and elimination of the salicylate is slower in camels than in sheep and goats.
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Selman I.E., Allan E.M., Dalgleish, R.G. (1986): The effect of flunixin meglumine and oxytetracycline therapy alone and in combination in calves with experimentally induced pasteurellosis. Proceeding of the 14th World Congress on Diseases of Cattle. Eds: Hartigan P.J. and Monaghan, M. L., pp606. University College of Dublin, Dublin, Ireland.
Selman I.E., Allan, M. Gibbs H.A., Wiseman A., Young W.B. (1984): Effect of anti-prostaglandin therapy in experimental parainfluenza type 3 pneumonia in weaned, conventional calves. Vet. Rec. 115, 101–105.
Nia, B., Vergnaud, J.M. (1996): Comparative pharmacokinetic of Aspirin 1000 mg i.v. versus 1000 mg i.m. thrice daily. Eur J Drug Metab Pharmacokinet., 21, 333–338.
Gingerich, D.A. and Baggot, J.D. and Yeary, R.A. (1975): Pharmacokinetics and dosage of aspirin in cattle. J. Amer. Vet. Med. Assoc., 167, 945–948.
Whittem, T., Freeman, D.A., Parton, K., and Hanlonm D.W. (1996): The Pharmacokinetics of salicylate in dairy cattle are not altered by simultaneous intravenous ceftiofur sodium and DL-lysine-acetyl salicylate (Aspirin). J. Vet. Pharmacol. Therap., 19, 104–108.
Davis, L.E. and Westfall, B.A. (1972). Species differences in biotransformation and excretion of salicylate. Amer. J. vet. Res., 33, 1253–1262.
Waters, D.J., Bowers, L.D., Cipolle, R.H., Caywood, D.D. and Bill, R.L. (1993): Plasma salicylate concentrations in immature dogs following aspirin administration: comparison with adult dogs. J. Vet. Pharmacol. Therap., 16, 275–282.
Ali, B.H., Cheng, Z., El Hadrami, G., Bashir, A.K. and McKellar, QA. (1996): Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goats. J. Vet. Pharmacol. Therap., 19, 238–224.
Ali, B.H., Wong, Y.C., Alhadrami, G.A., Charles, B.G. and Bashir, A.K. (1998): Plasma pharmacokinetics of intravenous and intramuscular furosemide in the camel (Camelus dromedarius). Res. Vet. Sci., 64, 69–72.
Ali, B.H. and Elsheikh, H.A. (1992): Some comparative aspects of drug metabolism in Nubiann goats (Capra hircus), desert sheep (Ovis aries) and dromedary camels (Camelus dromedarius). Comp. Biochem. Physiol. C, 101, 189–95.
Trinder, P. (1954): Rapid determination of salicylate in biological fluids. Biochem. J., 57, 301–303.
Gibaldi, M. and Perrier, D. (1982): Pharmacokinetics. 2nd edn, pp. 145–195. Marcel and Dekker Inc, New York.
Dawson, C.M., Wang, T.W.M., Rainbow, S.J., Tickner, T.R. (1988): A non-extraction HPLC method for the simultaneous determination of serum paracetamol and salicylate. Ann. Clin. Biochem., 25, 661–667.
Miners, J.O., Grgurinovich, N., Whitehead A.G., Robson, R.A., Brikett, D.J. (1986): Influence of gender and oral contraceptive steroids on the metabolism of salicylic acid and acetylsalicylic acid. Br. J. Clin. Pharmacol., 22, 135–142.
Trnavsky, K., Zachar, M.C. (1975): Correlation of serum aspirin esterases activity and half-life of salicylic acid. Agents Actions, 5, 549–554.
Lees, P. and Higgins, A.J. (1985): Clinical pharmacology and therapeutic uses of nonsteroidal and anti-inflammatory drugs in the horse. Equine Vet. J., 17, 83–96.
Van Miert, A.S.J.P.A.M. (1989): Extrapolation of pharmacological and toxicological data based on metabolic weight. Arch. Exp. Vet. Med. Med., 43, 481–488.
Abdalla, M.O., Abdalla, O. (1979): Morphometric observations on the kidney of camels. J. Anat., 129, 45–50.
Yagil, R. (1993): Renal function and water metabolism in the dromedary. Contrib. Nephron., 102, 161–70.
Ben-Zvi, Z., Goldin, G., Van Crevend, C. and Yagil, R. (1995): Lidocaine elimination and monoethlglycinexylidide formation in the dehydrated camels. J. Vet. Pharmacol. Therap., 18, 442–445.
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Ali, B.H. Comparative pharmacokinetics of salicylate in camels, sheep and goats. Eur. J. Drug Metab. Pharmacokinet. 28, 125–128 (2003). https://doi.org/10.1007/BF03190500
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DOI: https://doi.org/10.1007/BF03190500