Summary
Acetylator status was determined in 25 kwashiorkor children, aged between 8 months and 3 years and in 25 age-matched control group of healthy children after a single oral dose of sulphamethazine (40 mg/kg body weight) and by measuring the acetylated sulphamethazine in blood samples, collected 6 h after the administration of sulphamethazine. p ]The percentage of slow acetylators among kwashiorkor children was 40% while among the control group of children it was 48%. The difference between the two groups was not significant. p ]Therefore, it is probable mat the slow acetylator status of the Nigerian African children may not be a contributing factor for the development of kwashiorkor, a syndrome of protein-energy malnutrition. Furthermore, the polymorphic activity of N-acetyl transferase enzyme may not be impaired in kwashiorkor.
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Jeyakumar, L.H., Arowoshegbe, U.A., Akinyinka, O.O. et al. Acetylator status of kwashiorkor children in Ibadan (South-West Nigeria). Eur. J. Drug Metab. Pharmacokinet. 15, 57–62 (1990). https://doi.org/10.1007/BF03190128
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DOI: https://doi.org/10.1007/BF03190128