Summary
SK&F L-94901 is a novel thyromimetic, structurally related to thyroxine. The absorption, distribution, excretion and metabolism of radiochemically labelled [14C]-SK&F L-94901 has been investigated in the rat, dog and cynomolgus monkey. Oral absorption from solution was l ow or moderate in all three species. The compound was widely distributed and rapidly excreted, although traces of radioactivity were still evident in some tissues at 7 days post-dose, particularly in the kidney where radioactivity was located in an area approximating to the corticomedullary junction. Elimination of [14C]-SK&F L-94901 was both metabolic, mediated by the liver, and renal. The major metabolic routes of elimination were via oxidative deamination to lactate and acetate derivatives.
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Abbreviations
- m:
-
multiplet
- q:
-
quartet
- t:
-
triplet
- d:
-
doublet
- s:
-
singlet
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Pue, M.A., Ransley, J.A., Writer, D.J. et al. The disposition of SK&F L-94901, a selective thyromimetic in rat, dog and cynomolgus monkey. European Journal of Drug Metabolism and Pharmacokinetics 14, 209–219 (1989). https://doi.org/10.1007/BF03190101
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DOI: https://doi.org/10.1007/BF03190101