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Stability of disodium azodisalicylate (olsalazine) and metabolites in urine and faeces stored at different temperatures

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Summary

Methods: The stability of disodium azodisalicylate, 5-aminosalicylic acid and acetyl-5-aminosalicylic acid dissolved in distilled water and in urine or mixed with faeces to which HgCl2 was added, was studied at −20°C, 4°C and room temperature.

Results: In water, no marked differences were found between the three storage regimens. In urine, disodium azodisalicylate and acetyl-5-aminosalicylic acid were stable, while the 5-ASA concentration decreased when stored at 4°C and room temperature. In faeces stored during seven days, a marked decrease in 5-aminosalicylic acid concentration to about zero was found when it was kept at 4°C and room temperature. No marked change in the concentration of disodium azodisalicylate and 5-aminosalicylic acid added to the -HCl2-mixtures appeared.

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Authors and Affiliations

  1. Department of Medicine, Division of Gastroenterology, St. Radboud Hospital, Nijmegen, The Netherlands

    R. A. van Hogezand, A. van Schaik, P. A. M. van Hees & J. H. M. van Tongeren

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  1. R. A. van Hogezand
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  2. A. van Schaik
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  3. P. A. M. van Hees
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  4. J. H. M. van Tongeren
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van Hogezand, R.A., van Schaik, A., van Hees, P.A.M. et al. Stability of disodium azodisalicylate (olsalazine) and metabolites in urine and faeces stored at different temperatures. Eur. J. Drug Metab. Pharmacokinet. 13, 261–265 (1988). https://doi.org/10.1007/BF03190089

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  • DOI: https://doi.org/10.1007/BF03190089

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