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Influence of diet on the pattern of gastrointestinal biotransformation of netobimin and albendazole sulphoxide in sheep

European Journal of Drug Metabolism and Pharmacokinetics volume 24, pages 31–37 (1999)Cite this article

Summary

Thein vitro biotransformation of the anthelmintic compounds, netobimin (NTB) pro-drug and albendazole sulphoxide (ABZSO), by ruminal fluid obtained from sheep fed either hay or concentrate-based diets was investigated. No metabolic activity was observed in boiled samples of ruminal fluid, which confirms the importance of ruminal microflora in the metabolism of the xenobiotics under investigation. NTB pro-drug was efficiently biotransformed by ruminal fluidin vitro. Albendazole (ABZ) and its sulphoxide derivative were the metabolic products recovered. The thioether ABZ was formed by sulphoreduction of ABZSO by ruminal fluidin vitro. A more efficient nitroreduction of NTB and sulphoreduction of ABZSO were observed for ruminal fluid collected from sheep fed the concentrate diet. The type of diet determines the composition and distribution of the microbial population in the rumen; this affects the pattern of drug biotransformation in the gastrointestinal tract, which may impact on drug therapy.

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Affiliations

  1. Area Farmacología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro, Campus Universitario, 7000, Tandil, Argentina

    G. Virkel, A. Lifschitz, A. Pis & C. Lanusse

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  1. G. Virkel
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  2. A. Lifschitz
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  3. A. Pis
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  4. C. Lanusse
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Virkel, G., Lifschitz, A., Pis, A. et al. Influence of diet on the pattern of gastrointestinal biotransformation of netobimin and albendazole sulphoxide in sheep. Eur. J. Drug Metab. Pharmacokinet. 24, 31–37 (1999). https://doi.org/10.1007/BF03190008

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  • DOI: https://doi.org/10.1007/BF03190008

Keywords

  • Ruminal biotransformation
  • netobimin
  • albendazole sulphoxide
  • sheep