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Comparative bioavailability of Silipide, a new flavanolignan complex, in rats

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An Erratum to this article was published on 01 April 1992


The comparative pharmacokinetics of Silipide (IdB 1016, a silybin-phosphatidylcholine complex) and silybin were investigated by measuring unconjugated and total plasma silybin levels as well as total biliary and urinary silybin excretion in rats following administration of a single oral dose (200 mg/kg as silybin). Mean peak levels of unconjugated and total silybin after IdB 1016 were 8.17 and 74.23 μg/ml respectively. Mean AUC (0–6 h) values were 9.78 and 232.15 h.μ−1 indicating that about 94% of the plasma silybin is present in a conjugated form. After administration of silybin, plasma levels of both unconjugated and total compound were under the analytical detection limit. Cumulative biliary (0–24 h) and urinary (0–72 h) excretion values after administration of IdB 1016 accounted for 3.73% and 3.26% of the administered dose, respectively. After silybin administration, the biliary and urinary excretion accounted for only 0.001% and 0.032% of the dose respectively. Our results indicate a superior bioavailability of silybin administered orally as IdB 1016. This was due mainly to an impressive increase in gastrointestinal absorption.

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Morazzoni, P., Magistretti, M.J., Giachetti, C. et al. Comparative bioavailability of Silipide, a new flavanolignan complex, in rats. European Journal of Drug Metabolism and Pharmacokinetics 17, 39–44 (1992).

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