Summary
Co-administration of promethazine hydrochloride and chloroquine phosphate resulted in increased blood levels of chloroquine and its metabolites. However, there is no statistical difference between the means obtained for the initial rate of excretion and the total drug excreted within three hours.
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Chiba K., Yoshida M., Ishihara A., Sudo J., Tanabe T., Miyazaki S. and Takada M. (1985): Study of interactions between ibuprofen and sulphonamides, and between bucolome and sulphonamides in rats. Chem. Pharm. Bull., 33 (8), 3415.
Fitch C D., Chevli R. and Gonzalez Y. (1975): Chloroquine resistance in malaria. Variations of substratestimulated chloroquine accumulation. J. Pharmacol. Exp. Ther., 195 (3), 389.
Bewaja R., Sokoloski T.D. and Patik P.N. (1978): Competitive binding between cocaine and various drugs to synthetic levodopa melanin. J. Pharm. Sci., 66, 1544.
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Ehiemua, A.O., Komolafe, O.O., Oyedeji, G.A. et al. Effect of promethazine on the metabolism of chloroquine. European Journal of Drug Metabolism and Pharmacokinetics 13, 15–17 (1988). https://doi.org/10.1007/BF03189922
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DOI: https://doi.org/10.1007/BF03189922