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Absolute bioavailability of testosterone after oral administration of testosterone-undecanoate and testosterone

European Journal of Drug Metabolism and Pharmacokinetics volume 11, pages 145–149 (1986)Cite this article

Summary

The plasma levels of testosterone (T) were measured after oral administration of 25 mg T and 40 mg testosterone-undecanoate (TU) in a group of young women by a specific radioimmunoassay. Plasma levels were compared to those after intravenous administration of 1.5 ug testosterone/kg to another group of young women for determination of absolute bioavailability. Due to the high metabolic clearance rate of 24.5 ml/min/kg absolute systemic availability of free testosterone was calculated to 3.56±2.45%. Oral administration of testosterone undecanoate leads only to an absolute testosterone bioavailability of 6.8±3.32%.

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References

  1. Cantrill I.A., Dewis P., Large D.M., Newman M. and Anderson D.C. (1984): Which testosterone replacement therapy ? Clin. Endocrin.,21, 97–107.

    Article  CAS  Google Scholar 

  2. Schürmeyer T. and Nieschlag E. (1984): Comparative pharmacokinetics of testosterone enanthate and testosterone cyclohexanecarboxylate as assessed by serum and salivafy testosterone levels in normal man. Int. J. Androl.7, 181–187.

    Article  PubMed  Google Scholar 

  3. Murad F. and Haynes R.C. (1980): Androgens and anabolic steroids in : Goodman and Gilmans, The Pharmacological Basis of Therapeutics 6. Ed. MacMillan Publ. Co. New York, Toronto,London, 1448–1465.

    Google Scholar 

  4. Dagett P.R., Wheeler M.J. and Naborro J.D.N. (1978): Oral testosterone, a reappraisal. Hormone Res.,9, 121–129.

    Article  Google Scholar 

  5. Nieschlag E., Mauss J., Coert A. and Kicovic P. (1975): Plasma androgen levels in men after oral administration of testosterone or testosterone-undecanoate. Acta Endocrinol.,79, 366–374.

    CAS  PubMed  Google Scholar 

  6. Tamm J. (1967): Der Testosteronstoffwechsel beim Menschen. Dtsch. med. Wschr.,92, 2080–2086.

    CAS  PubMed  Google Scholar 

  7. Nieschlag E., Cüppers H.J. and Wickings E.J. (1977): Influence of sex, testicular development and liver function on the bioavailability of oral testosterone. Europ. J. Clin. Invest.,7, 145–147.

    Article  CAS  PubMed  Google Scholar 

  8. Southren A.K., Gordon G.G., Tochimoto S., Pinzon G., Lane D.R. and Stypulkowski W. (1967): Mean plasma concentration, metabolic clearance and basal plasma production rates of testosterone in normal young men a n d women using a constant infusion procedure: Effect of time of day and plasma concentration on the metabolic clearance rate of testosterone. J. Clin. Endocr.,27, 686–694.

    Article  CAS  PubMed  Google Scholar 

  9. Frey H., Aakwaag A., Saanum D. and Falich J. (1979): Bioavailability of oral testosterone in males. Eur. J. Clin. Pharmacol.,16, 345–349.

    Article  CAS  PubMed  Google Scholar 

  10. Schürmeyer T., Wickings e.J., Freischem L.W. and Nieschlag E. (1983): Saliva and serum testosterone following oral testosterone-undecanoate administration in normal and hypogonadal man. Acta Endocrinol.,102, 456–462.

    PubMed  Google Scholar 

  11. Horton T. and Tait J.F. (1966): Androstenedione production and interconversion rates measured in peripheral blood and studies on the possible sites of conversion of testosterone. J. Clin. Invest.,45, 301–313.

    Article  CAS  PubMed  Google Scholar 

  12. Coert A., Geelen J., de Vissier J. and van der Vies J. (1975): The Pharmacology and metabolism of testosterone-undecanoate (TU), a new orally active androgen. Acta Endocrinolgica,79, 789–800.

    CAS  Google Scholar 

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Affiliations

  1. Research Laboratories, D. Pharmacokinetics A, Schering AG, Müllerstrasse 170-178, D-1000, Berlin 65

    U. Täuber, K. Schröder, B. Düsterberg & H. Matthes

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  1. U. Täuber
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  2. K. Schröder
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  3. B. Düsterberg
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  4. H. Matthes
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Täuber, U., Schröder, K., Düsterberg, B. et al. Absolute bioavailability of testosterone after oral administration of testosterone-undecanoate and testosterone. European Journal of Drug Metabolism and Pharmacokinetics 11, 145–149 (1986). https://doi.org/10.1007/BF03189840

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  • DOI: https://doi.org/10.1007/BF03189840

Key-words

  • Testosterone
  • testosterone-undecanoate
  • absolute bioavailability
  • oral administration