Skip to main content
SpringerLink
Log in

Absence of rebound effect with calcium carbonate

  • Published:
European Journal of Drug Metabolism and Pharmacokinetics Aims and scope Submit manuscript

Summary

This was an open, randomised, balance cross-over study in 12 healthy male volunteers. The antacid activity of calcium carbonate plus magnesium carbonate (Rennie®) and hydrotalcite (Talcid®), given in the recommended dose of 2 tablets 4 times daily, were compared using 24 h intragastric measurement of pH. The volunteers received 2 tablets of calcium carbonate plus magnesium carbonate or hydrotalcite according to a randomised order 1 h after each meal and at bedtime.

Results showed that both treatments have similar antacid efficacy and a similar duration of action of about one hour. There was no evidence of acid ‘rebound’ following either treatment during the second and third hours following the administration of antacid.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Vatier J., Ramdani A., Vitré M.T., Mignon M. (1994): Antacid activity of calcium carbonate and hydrotalcite tablets. Comparison between in vitro evaluation using the ‘artificial stomach-duodenum’ model and in vivo pH-metry in healthy volunteers. Arzneimittelforschung., 44, 514–518.

    PubMed  CAS  Google Scholar 

  2. Yalow R.S., Berson S.A. (1970): Radioimmunoassay of gastrin. Gastroenterology, 58, 1–14.

    PubMed  CAS  Google Scholar 

  3. Peterson W.L., Sturdevant R.A.L., Frankl H.D. et al. (1977): Healing of a duodenal ulcer with antacid regimen. N. Engl. J. Med., 297, 341–345.

    Article  PubMed  CAS  Google Scholar 

  4. Tarnawski A. (1990): Cytoprotective drugs. Focus on antacids. Drug Invest., 2 (suppl. 1), 1–6.

    Google Scholar 

  5. Powell D.W. (1984): Physiological concepts of epithelial barriers. In: Allen A. et al. (eds.). Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract, New York: Raven Press, 1–5.

    Google Scholar 

  6. Weberg R., Berstad A., Lange O., Schulz T., Aubert E. (1985): Duodenal ulcer healing with four antacid tablets daily. Scand. J. Gastroenterol., 20, 1041–1045.

    Article  PubMed  CAS  Google Scholar 

  7. Rydning A., Weberg A., Lange O., Berstad A. (1986): Healing of benign gastric ulcer with low-dose antacids and fiber diet. Gastroenterology, 91, 56–61.

    PubMed  CAS  Google Scholar 

  8. Barreras R.F. (1970): Acid secretion after calcium carbonate in patients with duodenal ulcer. N. Engl. J. Med., 282, 1402–1405.

    Article  PubMed  CAS  Google Scholar 

  9. Reeder D.D., Conlee J.L., Thompson J.C. (1971): Calcium carbonate antacid and serum gastrin concentration in duodenal ulcer. Surg. Forum, 22, 308–310.

    PubMed  CAS  Google Scholar 

  10. Levant J.A., Walsh J.H., Isenberg J.I. (1973): Stimulation of gastric secretion and gastrin release by single oral doses of calcium carbonate in man. N. Engl. J. Med., 289, 555–558.

    Article  PubMed  CAS  Google Scholar 

  11. Fordtran J.S. (1968): Acid rebound. N. Engl. J. Med., 279, 900–905.

    Article  PubMed  CAS  Google Scholar 

  12. Brunton L.L. (1992): Agents for control of gastric acidity and treatment of peptic ulcers. In: Goodman & Gilman’s. The Pharmacological Basis of Therapeutics. 8th edn, Vol. II, 908.

  13. Schubert M.L., Edwards N.F., Makhlouf G.M. (1988): Regulation of gastric somatostatin secretion in the mouse by luminal acidity; a local feedback mechanism. Gastroenterology, 94, 317–322.

    PubMed  CAS  Google Scholar 

  14. Greenberg G.R., Fung L., Pokol-Daniel S. (1993): Regulation of somatostatin-14 and_-28 secretion by gastric acid in dogs: differential role of cholecystokinin. Gastroenterology, 105, 1387–1395.

    PubMed  CAS  Google Scholar 

  15. Hürlimann S., Michel K., Inauen W., Halter F. (1996): Effect of Rennie Liquid vs Maalox Liquid on the intragastric pH in a double-blind, randomized placebo controlled triple cross over study in healthy volunteers. Am. J. Gastroenterol., 91, 1173–1180.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinique Thérapeutique, Hôpital Lariboisière, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France

    G. Simoneau

Authors
  1. G. Simoneau
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Simoneau, G. Absence of rebound effect with calcium carbonate. European Journal of Drug Metabolism and Pharmacokinetics 21, 351–357 (1996). https://doi.org/10.1007/BF03189738

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03189738

Keywords

Search

Navigation