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Autoradiographic study of14C-Sulpiride in monkey

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Summary

Substituted benzamides have been the object of numerous metabolic studies including many by whole body autoradiography of rats and mice.

The present study reports autoradiographic data concerning14C-labelled Sulpuride in monkey. The Study was limited to the brain in order to elucidate the controversial question as to whether the drug can cross the blood-brain barrier. The results showed that in monkey, as in rat and mouse, there is no localization in the brain as can be clearly seen on the autoradiograms. In view of these results and of the undeniable neuroleptic properties of Sulpiride, an indirect mode of action through the release of endogenous mediators is proposed.

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Authors and Affiliations

  1. Laboratory of Drug Metabolism, Department of Pharmacology, University of Geneva, Switzerland

    A. Benakis

  2. Chemistry Department, Ghana Atomic Energy Commission, Legon, Accra, Ghana

    J. P. H. Brown

  3. Laboratoire de radioéléments et d’études métaboliques, Ecole Vétérinaire de Toulouse, France

    P. Benard

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  3. P. Benard
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Benakis, A., Brown, J.P.H. & Benard, P. Autoradiographic study of14C-Sulpiride in monkey. European Journal of Drug Metabolism and Pharmacokinetics 9, 365–370 (1984). https://doi.org/10.1007/BF03189687

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  • DOI: https://doi.org/10.1007/BF03189687

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