Summary
Effects of renal insufficiency on the pharmacokinetics of vinpocetine and its main metabolite, apovincaminic acid (AVA) were investigated in the present study. The elimination rate constant, half-life, clearance, area under the curve and volume of distribution were measured and compared with reported values for subjects with normal renal function. Previous investigations have shown that the elimination half life of vinpocetine was 2.54±0.48 hours and half-life of AVA was 3.66±1.56 hours in healthy volunteers after i. v. administration of 10 mg vinpocetine.
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Polgâr, M., Vereczkey, L.; in A. Frigerio (Editor), (1983): Recent Developments on Chromatography in Biochemistry, Medicine and Environmental Research, 1 (Proc. 1st Int. Symp., Venice, June 16–17, 1981), Elsevier, Amsterdam, Oxford, New York.
Polgár, M., Vereczkey, L. (1982): Determination of apovincaminic acid in human plasma by gas-liquid chromatography. J. Chrom. 241, 29–32.
Benakis, A., Plessas, Ch., Sugnaux, F. R., Bouvier, Cl., Reber, G. and Vereczkey, L. (1983): Pharmacokinetics of a new vasodilator drug, Vinpocetine (Cavinton ) in man. II. World Conference on Clinical Pharmacology and Therapeutics, Washington, USA, July 31–August 5, 1983.
Polgár, M., Vereczkey, L. (1983): Pharmacokinetics of vinpocetine after i.V., i-.m. and oral administration. Company Report No. RGD 27441.
Kozma, M., Vereczkey, L. (1982): Investigation of the pharmacokinetics of apovincaminic acid before and after the chronic oral administration of vinpocetine. Company Report No. RGD 25244.
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Miskolczi, P., Vereczkey, L., Szalay, L. et al. Pharmacokinetics of vinpocetine and apovincaminic acid in patients with impaired renal function. European Journal of Drug Metabolism and Pharmacokinetics 9, 169–175 (1984). https://doi.org/10.1007/BF03189621
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DOI: https://doi.org/10.1007/BF03189621