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Phenobarbital induction of procyclidine Metabolism: in vitro study

European Journal of Drug Metabolism and Pharmacokinetics volume 7, pages 229–231 (1982)Cite this article

Summary

After pretreatment of adult male Wistar rats with phenobarbital, a well-known cytochrome P-450 inductor, the liver microsomal cytochrome P-4S0 content increased significantly compared to that of control rats. At the same time the amount of procyclidine, metabolized by the 9000 g supernatant fraction of rat liver homogenate fortified with a NADPH generating system, increased significantly as well. However when related to the liver microsomal cytochrome P-450 content, the amount of metabolized procyclidine does not differ anymore between phenobarbital treated and control rats. Therefore phenobarbital induces the in vitro metabolism of procyclidine.

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Affiliations

  1. Department of toxicology, Free University Brussel, Brussel, Belgium

    G. Paeme, H. Van Bossuyt & A. Vercruysse

Authors
  1. G. Paeme
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  2. H. Van Bossuyt
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  3. A. Vercruysse
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Paeme, G., Van Bossuyt, H. & Vercruysse, A. Phenobarbital induction of procyclidine Metabolism: in vitro study. European Journal of Drug Metabolism and Pharmacokinetics 7, 229–231 (1982). https://doi.org/10.1007/BF03189569

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  • DOI: https://doi.org/10.1007/BF03189569

Key words

  • Procyclidine
  • metabolism
  • phenobarbital
  • induction
  • rat