Summary
After pretreatment of adult male Wistar rats with phenobarbital, a well-known cytochrome P-450 inductor, the liver microsomal cytochrome P-4S0 content increased significantly compared to that of control rats. At the same time the amount of procyclidine, metabolized by the 9000 g supernatant fraction of rat liver homogenate fortified with a NADPH generating system, increased significantly as well. However when related to the liver microsomal cytochrome P-450 content, the amount of metabolized procyclidine does not differ anymore between phenobarbital treated and control rats. Therefore phenobarbital induces the in vitro metabolism of procyclidine.
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Paeme, G., Van Bossuyt, H. & Vercruysse, A. Phenobarbital induction of procyclidine Metabolism: in vitro study. European Journal of Drug Metabolism and Pharmacokinetics 7, 229–231 (1982). https://doi.org/10.1007/BF03189569
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DOI: https://doi.org/10.1007/BF03189569