Summary
The pharmacokinetics of misonidazole, a hypoxic-cell radiosensitizer, were determinated after intraperitoneal administration to standardized Balb/c mice.
The experimental data was fitted, using non linear analysis, to plasma-concentration curves described by tri-exponential equations derived from a two-compartment model.
The pharmacokinetic constants (absorption and elimination coefficients) were determinated.
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Malmary-Nebot, MF., Labat, C., Terrissol, M. et al. Plasma concentrations and pharmacokinetics of misonidazole after intraperitoneal administration to the mouse. European Journal of Drug Metabolism and Pharmacokinetics 7, 17–20 (1982). https://doi.org/10.1007/BF03189538
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DOI: https://doi.org/10.1007/BF03189538