Summary
Metabolism of sodium dipropylacetate, a newly developed anticonvulsant, in human administered at a dose of 400 mg was investigated by gas chromatography-mass spectrometry. In the sera and urine obtained during the first 2 hr after the drug administration, a series of ßoxidative intermediates; 2-n-propylpenta-2-enoic acid, 2-n-propyl-3-hydroxypentanoic acid and 2-n-propyl-3-oxopentanoic acid were detected. In addition to the ß-oxidation, Ω-oxidation and glucuronide conjugation were shown to be involved in the metabolism of dipropylacetate by the identification of the glucuronide, 2-n-propyl-4-hydroxypentanoic acid, 2-n-propyl-5-hydroxypentanoic acid and 2-n-propylglutaric acid.
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Abbreviations
- DPA:
-
dipropylacetate
- TMS:
-
trimethylsilyl
- GC-MS:
-
gas chromatography-mass spectrometry
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Kuhara, T., Hirokata, Y., Yamada, S. et al. Metabolism of sodium dipropylacetate in human. European Journal of Drug Metabolism and Pharmacokinetics 3, 171–177 (1978). https://doi.org/10.1007/BF03189503
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DOI: https://doi.org/10.1007/BF03189503