Summary
An isolated perfused rat lung system has been used to study the deposition of the tobacco smoke particulate material marker3H-dotriacontane (3H-DOT) in the lung following inhalation of mainstream smoke from standard flue cured cigarettes labelled with 1 3 mCi3H-DOT. At the end of smoke exposure frozen sections of the lung were processed for autoradiography. Radioactivity occurred throughout the lung but was concentrated within small bronchi.
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Bibby, M.C., Gilpin, C.J., MacDonald, C.M. et al. Autoradiography of deposition of tobacco smoke particulate matter in isolated perfused rat lung. European Journal of Drug Metabolism and Pharmacokinetics 3, 141–145 (1978). https://doi.org/10.1007/BF03189498
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DOI: https://doi.org/10.1007/BF03189498