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Binding of digitoxin, digoxin and gitoxin to human serum albumin

  • Jean -Paul Tillement
  • Roland Zini
  • Michel Lecomte
  • Philippe d’Athis
Original Papers

Summary

The binding of three digitalis glycosides, digitoxin, digoxin and gitoxin, to human serum albumin was studied in vitro by equilib-rium dialysis. The results obtained showed that binding is a non saturable process and that probably the same binding mechanism is involved for each of the three drugs. Their binding sites seem to be different from of those of acidic and basic drugs. However, the three drugs were found to be partially displaced by large amounts of fatty acids.

Key-words

Digitoxin digoxin gitoxin human serum albumin protein binding 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Jean -Paul Tillement
    • 1
  • Roland Zini
    • 1
  • Michel Lecomte
    • 2
  • Philippe d’Athis
    • 3
  1. 1.Département de PharmacologicFaculté de Médecine de Paris XIICréteilFrance
  2. 2.Laboratoire de Physiologie et de Pharmacologie du Département de Biologie Appliquée (Pr. Boulouard), Institut Universitaire de TechnologieUnviersité de Paris XIICréteilFrance
  3. 3.Département d’informatique Médicale (pr Ag. L. Dusserre)Hôpital du BocageDijonFrance

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