Summary
A ten-compartment analog computer model is presented to determine the precise distribution and excretion of two antidepressant drugs, LM 5008 and Imipramine. Eight patterns were simulated using experimental data and drug distribution in the two undetermined compartments were obtained by the analog model. Close agreement with existing experimental data lends confidence in the model as a valuable tool for predictions in a variety of therapeutic situations.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Wagner J.G. (1971): Biopharmaceutics and Relevant Pharmacokinetics. Drug Intelligence Publications, Hamilton, Ill.
Swarbrick J. (1970): Current Concepts in the Pharmaceutical Sciences: Biopharmaceutics, Lea and Febiger, Philadelphia.
Le Fur G. and Uzan A. (1977): Effects of 4-(3-indolyl-alkyl) piperidine derivatives on uptake and release of noradrenaline, dopamine and 5-hydroxytryptamine in rat brain synapto-somes, rat heart and human blood platelets. Biocherh. Pharmacol.,26, 497–503.
Le Fur G., Mitrani N. and Uzan A. (1977): Effects of 4-(3-indolyl-alkyl)piperidine derivatives on brain 5-hydroxy-tryptamine turnover and on cardiac and brain noradrenaline or 5-hydroxytryptamine depletion induced by 6-hydroxy-dopamine, H75/12 and 4-chloroamphetamine. Biochem. Pharmacol.,26, 505–509.
Mizoule J., Mitrani N., Le Fur G. et Uzan A. (1977): L’antagonisme du ptosis réserpinique chez le lapin, un test d’activité antidépressive sérotonino-dépendant? J. Pharmacol. (Paris),8 (3), 269–285.
Le Fur G., Kabouche M. and Uzan A. (1978): On the regional and specific serotonin uptake inhibition by LM 5008. Life Sciences,23, 1959–1966.
Uzan A., Gueremy C. et Le Fur G. (1976): Métabolisme de la (quinuclidinyl-3 méthylHO phénothiazine (LM 209), un nouvel anti-allergique. I. Absorption, distribution et excrétion. Xenobiotica,6 (10), 633–648.
Cavillito C.J. (1959): Transactions International Symposium on curare and Curare-like Substances, Elvesier Publishing Co., Amsterdam, p. 288.
Cohen E.N., Borbascio A. and Fleischli G. (1965): The distribution and fate of d-tubocurarine. J. Pharmacol. Exp. Therap.,147 (1), 120–129.
Author information
Authors and Affiliations
Additional information
Indalpine: Proposed INN, LM 5008
Rights and permissions
About this article
Cite this article
Le Fur, G., Amouroux, J., Roquet, F. et al. Comparative distribution of two antidepressant drugs (imipramine and indalpine) in the rat as determined by analog computer simulation. European Journal of Drug Metabolism and Pharmacokinetics 4, 9–14 (1979). https://doi.org/10.1007/BF03189393
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03189393