Summary
The differential distribution of antitumoral agents such as adriamycin, methylnitrosourea, cyclophosphamide and methotrexate in the vegetating and necrotic part of the intramuscular Lewis Lung carcinoma of C57B1 mice is investigated.
As expected, these drugs are found to be mostly absent in the necrotic, while accumulating in the viable part of the tumor. Our findings suggest that measurement of antitumoral agents at the tumor level should be performed in the viable part of the tumor in order to get a proper estimate of the actual drug concentrations reached.
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Donelli, M.G., Broggini, M., Colombo, T. et al. Importance of the presence of necrosis in studying drug distribution within tumor tissue. European Journal of Drug Metabolism and Pharmacokinetics 2, 63–67 (1977). https://doi.org/10.1007/BF03189285
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DOI: https://doi.org/10.1007/BF03189285