Summary
Percutaneous absorption of3H-Flupamesone was studied in human subjects after being incorporated into 2 bases. The radioactivity was measured in the whole blood, plasma, urine and feces. The amount of administered radioactivity recovered from the urine during 5 days is between 0.2 and 0.3 % for both forms of the product.
References
Rimbau, V. and Lleonart, F., 1975, Kinetic study of the percutaneous absorption of 1, 2, 4-3H-labelled-flupamesone. Arzneim. Forsch.:25, 1040–1042.
Corominas, F. and Goday, A., 1974, Experiencia clinica en doble ciego con flupamesona (UR-105) y acetónido de triamcinolona. Actual. Dermatol.,14 (4), 21–24.
Rodriguez-Moreno, T. and Rodriguez-Canas, T., 1976, Tratamiento local con flupamesona. Ensayo doble ciego con fluocinolona acetonido. Rev. Clin. Esp., 142 (3), 255–260.
Rodriguez-Moreno, T., Rodriguez-Canas, T. and Morell, J., Topical treatment of eczema with flupamesone (Flutenal): A double-blind comparison with betamethasone-17-valerate. Curr. Ther. Res. In press.
Rimbau, V., 1974, Aplicaciones de los isótopos radioactivos al estudio de la absorción dérmica de corticosteroides. Antol. Dermatol.,4 (4), 11–19.
Lewis, J. D., Cameron, B. D., Hawkins, D. R., Chasseaud, L. F. and Franklin, E. R., 1975, Percutaneous absorption of14C-9 -αfluor-11 β, 21-dihydroxy-3, 20-dioxopregna-1, 4-dieno [17 α, 16 α-d]-2′-methyloxazoli-dine-21-acetate (L-6400) in rats, pigs and humans. Arzneim. Forsch.,25, 1646–1650.
James, M., Marty, J. P. and Wepierre, J., 1976, Percutaneous absorption of dexamethasone-3H in rats and mice: comparative study with oral administration. Europ. J. of Drug Metab. and Pharmacokinetics,1 (2), 69–72.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rimbau, V., Forn, J., Delgado, C. et al. Percutaneous absorption of3H-labelled flupamesone in man. European Journal of Drug Metabolism and Pharmacokinetics 1, 206–207 (1976). https://doi.org/10.1007/BF03189280
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03189280