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The role of Dextran on the blood level of35S-Calcium Dobesilate in humans

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Summary

The concomitant administration of Dextran and Calcium Dobesilate might be foreseen in clinical practice since the former is used as a blood volume restorer, and the latter as a protector of the capillary blood vessel walls. The aim of this study is to investigate if the intravenous administration of Dextran is liable to influence the pharmacokinetics of orally administrated 35S Calcium Dobesilate. The maximum blood level values in the group treated simultaneously with Calcium Dobesilate and Dextran were similar to those obtained after the administration of Calcium Dobesilate alone. The rate of protein binding was practically identical in both Dextran-treated groups, whether Calcium Dobesilate was given before or after Dextran. This experiment showed that Dextran does not affect the blood level of Calcium Dobesilate in man.

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Authors and Affiliations

  1. Experimental Pharmacology Laboratory of the University of A thens, 22, Ilidos Street, 608, Athens, Greece

    Ch. -T. Plessas & D. Varonos

  2. Cardiological Clinic, R. Paul Hospital, Athens

    S. T. Plessas, D. Cokkinos & E. Voridis

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  1. Ch. -T. Plessas
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  2. D. Varonos
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  3. S. T. Plessas
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  4. D. Cokkinos
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  5. E. Voridis
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Plessas, C.T., Varonos, D., Plessas, S.T. et al. The role of Dextran on the blood level of35S-Calcium Dobesilate in humans. European Journal of Drug Metabolism and Pharmacokinetics 1, 125–127 (1976). https://doi.org/10.1007/BF03189266

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  • DOI: https://doi.org/10.1007/BF03189266

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