Summary
The effect of the female rat estral cycle on microsomal drug metabolism in-vivo and in-vitro has been studied. Two microsomal enzymes, aminopyrine-N-demethylase and aniline hydroxylase showeda greater specific activity (p<0.01 ) in the diestrus phase of the estral cycle while the oxidative enzyme aryl hydrocarbon hydroxylase and the conjugative enzyme, glucuronyl transferase, were not affected. In vivo studies which included theophylline and antipyrine metabolism, and hexobarbital sleeping times showed no difference between the different phases of the estral cycle. Conflicting evidence about the effect of steroid sex hormones on hepatic drug metabolism is discussed.
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Brandstetter, Y., Kaplanski, J., Leibson, V. et al. The effects of estrus cycle on drug metabolism in the rat. European Journal of Drug Metabolism and Pharmacokinetics 11, 251–254 (1986). https://doi.org/10.1007/BF03189109
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DOI: https://doi.org/10.1007/BF03189109