Summary
Fendiline was administered intravenously (3 mg) and orally (50 mg and 75 mg) in a cross-over study to six healthy volunteers. The plasma levels of unchanged fendiline and of total radioactivity were measured. Fendiline was absorbed well and its concentration declined biexponentially with mean terminal half-lives of 20–35 h. Since the drug is extensively metabolized, only 12% of total radioactivity in plasma corresponded to fendiline in the case of intravenous administration as compared to less than 2% after oral administration. 56–65% of the administered dose are excreted via the urine and 18–25% with the feces within five days.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Benthe, H.F., Thieme, R. (1979): Metabolism of DL-Fendiline in Man. Naunyn-Schmiedeberg’s Arch. Pharmacol.,308 Suppl., R 21.
Eichelbaum, M., Ende, M., Remberg, G., Schomerus, M., Dengler, H.J. (1979): The Metabolism of DL-(14C) Verapamil in Man. Drug Metab. Dispos.,7, 145–148.
Remberg, G., Eichelbaum, M., Spiteller, G., Dengler, H.J. (1977): Metabolism of DL-(14C) Prenylamine in Man. Biomed. Mass Spectrom.,4, 297–304.
Schomerus, M., Spiegelhalder, B., Stieren, B., Eichelbaum, M. (1976): Physiological Disposition of Verapamil in Man. Cardiovasc. Res.,10, 605–612.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kukovetz, W.R., Brunner, F., Beubler, E. et al. Single dose pharmacokinetics of fendiline in humans. European Journal of Drug Metabolism and Pharmacokinetics 7, 105–110 (1982). https://doi.org/10.1007/BF03188726
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03188726