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The new sideway of CNTF signal transduction pathway

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Chinese Science Bulletin

Abstract

The action of ciliary neurotrophic factor (CNTF) on intercellular free Ca2+ concentrations [Ca2+]i induced by glutamate (Glu) in primary cultured hippocampal neurons were detected with Fura2/AM, a Ca2+-sensitive fluorophore, and the morphological influence of G-protein on it was objected. Glu could induce rapid increase of [Ca2+]i in hippocampal neurons. CNTF had no significant action on [Ca2+]i in resting hippocampal neurons. However, after incubation of CNTF for 5 min, the increase of [Ca2+]i in hippocampal neurons rapidly induced by Glu was inhibited. Pretussis toxin (PTX)-sensitive G protein could block the action. These results indicate that a new non-genomic rapid sideway might exist in the upper stream of CNTF signal transduction pathway, which was related to Ca2+ signal transduction.

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References

  1. Inoue, M., Nakayama, C., Noguchi, H., Activating mechanism of CNTF and related cytokines, Mol. Neurobiol., 1996, 12(3): 195.

    Article  Google Scholar 

  2. Mufson, E. L., Kroin, J. S., Sendera, T. J. et al., Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases, Prog. Neurobiol., 1999, 57(4): 451.

    Article  Google Scholar 

  3. Ip, N. Y., The neurotrophins and neuropoietic cytokines: two families of growth factors acting on neural and hematopoietic cells, Annals of the New York Academy of Sciences, 1998, 840: 97.

    Article  Google Scholar 

  4. Nagtegaal, I. D., Lakke, E. A. J. F., Marani, E., Trophic and tropic factors in the development of the central nervous system, Archives of Physiology and Biochemistry, 1998, 106(3): 161.

    Article  Google Scholar 

  5. Espat, N. J., Auffenberg, T., Rosenberg, J. J. et al., Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response, Am. J. Physiol., 1996, 271(1 Pt 2): R185.

    Google Scholar 

  6. Dittrich, F., Thoenen, H., Sendtner, M., Ciliary neurotrophic factor: pharmacokinetics and acute-phase response in rat, Neurology, 1994, 44(3 Pt 1): 488.

    Google Scholar 

  7. Ghezzi, P., Ciliary neurotrophic factor inhibits brain and peripheral tumor necrosis factor production and, when coadministered with its soluble receptor, protects mice from lipoB, fast action of neurotrophic factors, Current Opinion in Neurobiology, 1996, 6: 324.

    Article  Google Scholar 

  8. Stoop, R., Poo, M. M., Potentiation of transmitter release by ciliary neurotrophic factor requires somatic signaling, Science, 1995, 267(5198): 695.

    Article  Google Scholar 

  9. Henderson, J. T., Seniuk, N. A., Roder, J. C., Localization of CNTF immunoreactivity to neurons and astroglia in the CNS, Brain Res. Mol. Brain Res., 1994, 22(1-4): 151.

    Article  Google Scholar 

  10. Watanabe, D., Yoshimura, R., Khalil, M. et al., Characteristic localization of gpl30 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain, Eur. J. Neurosci., 1996, 8(8): 1630.

    Article  Google Scholar 

  11. Lee, M. Y., Hofmann, H. D., Kirsch, M., Expression of ciliary neurotrophic factor receptor-alpha messenger RNA in neonatal and adult rat brain: anin situ hybridization study, Neuroscience, 1997, 77(1): 233.

    Article  Google Scholar 

  12. Kordower, J. H., Chu, Y. P., Maclennan, A. J., Ciliary neurotrophic factor receptor alpha-immunoreactivity in the monkey central nervous system, J. Comp. Neurol., 1997, 377(3): 365.

    Article  Google Scholar 

  13. Nakanishi, S., Nakajima, Y., Masu, M. et al., Glutamate receptors: brain function and signal transduction, Brain Res. Brain Res. Rev., 1998, 26(2-3): 230.

    Article  Google Scholar 

  14. Carter, S. C., Smit, L. S., Signaling via JAK tyrosine kinases: growth hormone receptor as a model system, Recent. Prog. Horm. Res., 1998, 53: 61.

    Google Scholar 

  15. Heim, M. H., The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus, J. Recept. Signal. Transduct. Res., 1999, 19(1-4): 75.

    Article  Google Scholar 

  16. Rudge, J. S., Pasnikowski, E. M., Holst, P. et al., Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acid, J. Neurosci., 1995, 15(10): 6856.

    Google Scholar 

  17. Stoop, R., Poo, M. M., Synaptic modulation by neurotrophic factors: differential and synergistic effects of brain-derived neurotrophic factor and cilliary neurotrophic factor, Proc. Natl. Acad. Sci. USA, 1996, 93(14): 7346.

    Article  Google Scholar 

  18. Heuss, C., Scanziani, M., Gahwiler, B. H. et al., G-protein-independent signaling mediated by metabotropic glutamate receptors, Nature Neuroscience, 1999, 2(12): 1070.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Neurobiology, Second Military Medical University, 200433, Shanghai, China

    Jin Yan, Cheng He, Changlin Lu & Chenghai Wang

  2. Department of Psychology, Second Military Medical University, 200433, Shanghai, China

    Jin Yan

  3. Shanghai Brain Institute, Chinese Academy of Sciences, 200031, Shanghai, China

    Xuan Bao

  4. Laboratory of Molecular Developmental Biology, Institute of Developmental Biology, Chinese Academy of Sciences, 100080, Beijing, China

    Tieshan Tang, Xiuying Huang & Fangzhen Sun

Authors
  1. Jin Yan
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  2. Cheng He
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  3. Changlin Lu
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  4. Chenghai Wang
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  5. Xuan Bao
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  6. Tieshan Tang
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  7. Xiuying Huang
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Correspondence to Jin Yan or Changlin Lu.

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Yan, J., He, C., Lu, C. et al. The new sideway of CNTF signal transduction pathway. Chin.Sci.Bull. 46, 477–480 (2001). https://doi.org/10.1007/BF03187260

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  • DOI: https://doi.org/10.1007/BF03187260

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