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Matrix metalloproteinases (MMPs) and trophoblast invasion

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Chinese Science Bulletin

Abstract

MMPs and their natural tissue inhibitors TIMPs are crucial in coordinated breakdown and remodeling of the extracellular matrix (ECM) in physiological and pathological situations. Placentation is a key event of pregnancy in which MMPs/TIMPs system plays important roles in regulating the extravillus cytotrophoblast (EVTs) invasion. This paper focuses on expression patterns and regulatory mechanisms of MMPs/TIMPs family members during the process of placentation. Their implications in curing pregnancy-related diseases are also discussed.

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Authors and Affiliations

  1. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080, Beijing, China

    Jing Li & Enkui Duan

  2. Graduate School of the Chinese Academy of Sciences, 100039, Beijing, China

    Jing Li

  3. Department of Biology, Baoding Teacher’s College, 071000, Baoding, China

    Tianfu Zhao

Authors
  1. Jing Li
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  2. Tianfu Zhao
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  3. Enkui Duan
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Correspondence to Enkui Duan.

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Li, J., Zhao, T. & Duan, E. Matrix metalloproteinases (MMPs) and trophoblast invasion. Chin.Sci.Bull. 50, 1169–1173 (2005). https://doi.org/10.1007/BF03183688

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  • DOI: https://doi.org/10.1007/BF03183688

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