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Functions of VEGF in female reproductive system

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Chinese Science Bulletin

Abstract

As a homodimeric glycoprotein, vascular endothelial growth factor (VEGF) is a highly specific mitogen of vascular endothelial cells. It can induce proliferation and migration, and inhibit apoptosis of endothelial cell. VEGF is involved in many processes in the female reproductive system, such as ovulation, periodical changes of endometrium, embryo implantation and development. VEGF plays important roles in some reproductive diseases, including preeclampsia and fetal hypoevolutism in uterus. Based on our studies on angiogenesis and its relevant factors in the female reproductive system these years, the functions of VEGF in female reproductive system are reviewed, and the research prospect and application of VEGF are also discussed.

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Authors and Affiliations

  1. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080, Beijing, China

    Qian Dong & Zhu Cheng

Authors
  1. Qian Dong
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  2. Zhu Cheng
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Correspondence to Zhu Cheng.

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Dong, Q., Cheng, Z. Functions of VEGF in female reproductive system. Chin.Sci.Bull. 48, 217–222 (2003). https://doi.org/10.1007/BF03183286

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  • DOI: https://doi.org/10.1007/BF03183286

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