Abstract
A furanofuranoid lignan glycoside, with radical scavenging on peroxynitrite, total reactive oxygen species (ROS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, was isolated from the rhizome ofSalvia miltiorrhiza and characterized as (+)-1-hydroxypinoresinol-1-O-β-d-glucoside based on spectroscopic evidence. The compound exhibited peroxynitrite, total ROS and DPPH radical scavenging activities with IC50 values of 3.23 ± 0.04, 2.26 ± 0.07 and 32.3 ± 0.13 μM, respectively. Penicillamine, Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) andL-ascorbic acid, acting as positive controls, showed radical scavenging activities with IC50 values of 6.72 ± 0.25, 1.43 ± 0.04 and 11.4 ± 0.07 μM, respectively.
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Kang, H.S., Chung, H.Y., Byun, D.S. et al. Further isolation of antioxidative (+)-1-hydroxypinoresinol-1-O-β-d-glucoside from the rhizome ofSalvia miltiorrhiza that acts on peroxynitrite, total ROS and 1,1-diphenyl-2-picrylhydrazyl radical. Arch Pharm Res 26, 24–27 (2003). https://doi.org/10.1007/BF03179926
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DOI: https://doi.org/10.1007/BF03179926