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Proceedings: Animal Sciences

, Volume 95, Issue 2, pp 263–268 | Cite as

Implantation delay and nidation by progesterone in carrot seed (Daucus carota) extract treated albino rats

  • B B Kaliwal
  • R Nazeer Ahamed
  • M Appaswamy Rao
Article
  • 32 Downloads

Abstract

In the present study the effect of petroleum ether extract of carrot seeds and progesterone on implantation have been investigated. 0·6 ml/100 g body weight of carrot seed extract was administered subcutaneously from days 1–7 of pregnancy and laparatomized on day 8. No implantation sites were observed. Thereafter graded doses of progesterone 2, 4 or 8 mg/100 g body weight was administered upto day 15 and autopsied on day 16. Two mg of progesterone did not show any effect. However, 4 mg of progesterone treated rats had smaller implantation sites compared to the controls whereas, 8 mg of progesterone was most effective with the result that in almost all the rats, delayed implantation was observed.

Keywords

Implantation carrot seed extract progesterone albino rats 

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References

  1. Briggs M H and Christie G A 1977 Antifertility substances in plants;Adv. Steroid. Biochem. Pharmacol. 6 XI-XIXGoogle Scholar
  2. Burdick H O, Whitney R and Pincus G 1937 The fate of mouse ova, tube locked by injections of oestrogenic substances;Anat. Rec. 67 5131CrossRefGoogle Scholar
  3. Casey R C D 1960 Alleged antifertility plants of India;Indian J. Med. Sci. 14 590PubMedGoogle Scholar
  4. Chang M C and Yanagimachi R 1965 Effect of estrogens and other compounds as a oral antifertility agent on the development of rabbit ova and hamster embryo;Fertil. Steril. 16 281–291PubMedGoogle Scholar
  5. Cochrane R L and Meyer R K 1957 Delayed nidation in the rat induced by progesterone;Endocrinology 96 155Google Scholar
  6. Farnsworth N R, Bingel A S, Cordell G A, Crane F A and Fong M H S 1975 Potential value of plants as sources of new antifertility agents-1;J. Pharmacol. Sci. 64 535–598CrossRefGoogle Scholar
  7. Garg S K and Garg G P 1971 Antifertility screening of plants (Part VII). Effect on pregnancy in albino rats;Indian J. Med. Res. 59 307Google Scholar
  8. Kaliwal B B and Appaswamy Rao M 1977 Inhibition of implantation by carrot extract and its rectification in albino rats;J. Karnatak. Univ. Sci. 22 167–172Google Scholar
  9. Kaliwal B B and Appaswamy Rao M 1979 Dose and durational effect of carrot seed extract on implantation in albino rats;Comp. Physiol. Ecol. 4 92–97Google Scholar
  10. Kholkute S D and Udupa K N 1976 Effect ofHibiscus rosa sinensis on pregnancy of rat;Plant Medica.29 321–329CrossRefGoogle Scholar
  11. Morris J M, Van Wagenen B, McCann T and Jacob D 1967 Compounds interfering with ovum implantation and development. II. Synthetic estrogens and antiestrogens;Fertil. Steril. 18 18–34PubMedGoogle Scholar
  12. Nutting E F and Meyer R K 1965Implantation delay, nidation and embryonic survival in rats treated with ovarian hormones. In delayed implantation (ed.) A C Enders (University of Chicago Press) p 233Google Scholar
  13. Prasad M R N, Kalra S P and Segal S J 1965 Effect of Clomiphene on blastocysts during delayed implantation in the rats;Fertil. Steril. 6 101–105Google Scholar
  14. Prasad M R N and Kalra S P 1967 Mechanism of anti-implantation action of Clomiphene;J. Reprod. Fertil. 13 59–66PubMedCrossRefGoogle Scholar
  15. Sharma M M, Lal G and Jacob D 1976 Estrogenic and pregnancy interceptory effect of carrot,Daucus carota seeds;Indian. J. Exp. Biol. 14 506–508PubMedGoogle Scholar
  16. Shelesnyak M C, Kraicer S P and Zeilmaker G H 1963 Studies on the mechanism of decidualization. I. The oestrogen surge of pseudopregnancy and progravidity and its role in the process of decidualization;Acta Endocrinol. Kbh. 42 225–232Google Scholar

Copyright information

© Indian Academy of Sciences 1986

Authors and Affiliations

  • B B Kaliwal
    • 1
  • R Nazeer Ahamed
    • 1
  • M Appaswamy Rao
    • 1
  1. 1.Department of ZoologyKarnatak UniversityDharwadIndia

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