Abstract
Alterations in haematological and liver glycogen values during the course ofAncylostoma ceylanicum (100L3, p.o.) infection in hamsters were investigated. In early phase of infection, there were marginal changes in haematological parameters, albuminglobulin ratio and liver glycogen, which transformed into severe alterations on patency (day 18, post infection). Haemoglobin, packed cell volume, total erythrocyte counts and liver glycogen values had a decreasing trend and reticulocytes increased considerably to compensate the red blood cell loss. Albumin/globulin ratio which was in favour of albumin in the beginning, reversed on day 24 p.i. When the animals were deparasitized with mebendazole (5 mg/kgxl, p.o.), all the parameters started resuming normalcy and on day 12 of treatment of all the parameters except albumin/globulin ratio attained the preinfection level.
Similar content being viewed by others
References
Anon 1978Manual of Veterinary investigation laboratory technique, Part 4. Haematology 2nd edition (London: Ministry of Agriculture, Fisheries and Food)
Baker N F 1962 The nature and etiology of the leukocyte response of Webster mice infected withNematospiroides dubium;J. Parasitol. 48 438–441
Boyer M H, Spry C J F, Beeson P B and Sheldon W H 1971 Mechanism of eosinophilia IV. The pulmonary lesion resulting from intravenous injection ofTrichinella spiralis;Yale J. Biol. Med. 43 351–356
Briero R O and Mull J D 1964 Electrophoresis of serum proteins with cellulose acetate;Am. J. Clin. Pathol. 42 547–551
Carroll S M and Grove D I 1985Ancylostoma ceylanicum: immunization with soluble worm extract and responses to challenge infection of dogs;Exp. Parasitol. 60 263–267
Chatterjee K D 1967Phylum nemathelminthes—Ancylostoma duodenale parasitology (protozoology and helminthology) in relation to clinical medicine (Calcutta, India: Chatterjee Medical Publishers) VI edition
Cheema K J and Scofield A M 1984 The influence of level of infection of ratsNippostrongylus brasiliensis on the haematology and phospholipaseactivity and mast cell numbers in the small intestine and colon;Int. J. Parasitol. 15 55–60
Good A, Kramar H G and Somagyi M 1933 The determination of glycogen;J. Bio. Chem. 100 485–491
Gupta S and Katiyar J C 1985 Immunological response of hamster toAncylostoma ceylanicum infection;Helminthologia 22 181–184
Gupta S, Srivastava J K and Katiyar J C 1987Ancylostoma ceylanicum: migratory behaviour in golden hamsters after oral and parenteral infection;Ann. Trop. Med. Parasitol. 81 412–442
Hoagland K E and Schad G A 1978Necator americanus andAncylostoma duodenale: Life history parameters and epidimiological implication of two sympatric hookworms of humans;Exp. Parasitol. 44 36–49
Jane M P 1979Beckman, microzone electrophoresis manual (California: Beckman Instrument. Inc. Fullerton)
Katiyar J C, Visen P K S, Gupta S, Sen A B, Dubey S K and Sharma S 1982 3,5-Dibroma-2′-chloro-4′-isothiocynato salicylanilide, a potent anthelmintic;Experientia 38 457–459
Katiyar J C, Visen P K S, Misra A, Gupta S and Bhaduri A P 1984 Methyl 5(6)-4-2-pyridyl piperazino carbamoyl benzimidazole-2-carbamate-a new broad spectrum anthelmintic;Acta Trop. 41 279–286
Kaul G L, Talwalker P K, Sen H G and Grewal R S 1982 Changes in carbohydrate metabolism in golden hamsters infected withNecator americanus;Ann. Trop. Med. Parasitol. 76 475–482
Misra A, Visen P K S and Katiyar J C 1981 Comparative efficacy of standard antihookworm drugs against various nematodes;J. Helminthol. 55 273–278
Montgomery R 1957 Determination of glycogen;Arch. Biochem. Biophys. 67 378–386
Maqbel R 1980 Histological changes following primary secondary and repeated infections of rats withStrongyloides ratti, with special reference to tissue eosinophils;Parasite Immunol. 2 11–27
Ogilvie B M, Hesketh P M and Rose M E 1978Nippostrongylus brasiliensis: peripheral blood leucocyte response of rats, with special reference to basophils;Exp. Parasitol. 46 20–30
Ogilvie B M, Askenase P W and Rose M E 1980 Basophils and eosinophils in three strains of rats and in athymic (nude) rats following infection with nematodesNippostrongylus brasiliensis orTrichinella spiralis;Immunology 39 385–389
Przyjalkowski Z, Kontny E and Cabaj W 1980 Haematological changes evoked byTrichinella spiralis as an index of the course of trichinellosis in germ free and conventional mice;Bull. Acad. Pol. Sci. 28 87–93
Ray D K, Bhopale K K and Srivastava V B 1972 Migration and growth ofAncylostoma ceylanicum (Looss 1911) in golden hamstersMesocricetus auratus;J. Helminthol. 46 357–362
Roach M 1970 Ancylostomiasis and anaemia;Biol. Sanit. Panam. 69 221–228
Roth R L and Levy D A 1980Nippostrongylus brasiliensis: peripheral leukocyte responses and correlation of basophils with blood histamine concentration during infection in rats;Exp. Parasitol. 50 331–341
Ruitenberg E J, Elgersma A, Kruizinga W and Leenstra F 1977Trichinella spiralis infection in congenitally athymic (nude) mice. Parasitological, serological and haematological studies with observations on intestinal pathology;Immunology 33 581–587
Srivastava J K, Gupta S and Katiyar J C 1986 Behavioural studies on the arrestedAncylostoma ceylanicum larvae in hamsters;Riv. Parasitol. III (XLVII) 447–454
Symons L E A 1969 Pathology of gastrointestinal helminthiases;Int. Rev. Trop. Med. 3 49–100
Visen P K S, Katiyar J C and Sen A B 1984 Studies on infectivity, longevity and fecundity ofAncylostoma ceylanicum in golden hamsters;J. Helminthol. 58 159–164
Wakelin D and Donachie A M 1983 Genetic control of eosinophilia. Mouse strain variation in response to antigens of parasitic origin;Clin. Exp. Immunol. 51 239–246
Author information
Authors and Affiliations
Additional information
CDRI communication No. 4211.
Rights and permissions
About this article
Cite this article
Srivastava, J.K., Gupta, S. & Katiyar, J.C. Haemodynamics of hamsters duringAncylostoma ceylanicum infection. Proc. Indian Acad. Sci. (Anim. Sci.) 97, 491–497 (1988). https://doi.org/10.1007/BF03179550
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03179550