Abstract
The main aim of this study was to examine the hypothesis that creatine (Cr) feeding enhances myocellular glycogen storage in humans undergoing carbohydrate loading. Twenty trained male subjects were randomly assigned to have their diets supplemented daily with 252 g of glucose polymer (GP) and either 21 g of Cr (CRGP, n=10) or placebo (PL-GP, n=10) for 5 days. Changes in resting myocellular glycogen and phosphocreatine (PCr) were determined with Magnetic Resonance Spectroscopy (13C- and31P-MRS, respectively). After CR-GP, the levels of intramyocellular glycogen increased from 147±13 (standard error) mmol·(kg wet weight)−1) to 182±17 mmol·(kg wet weight)−1, while it increased from 134±17 mmol·(kg wet weight)− to 182±17 mmol·(kg wet weight)−1 after PL-GP; the increments in intramyocellular glycogen concentrations were not statistically different. The increment in the PCr/ATP ratio after CR-GP (+0.20±0.12) was significantly different compared to PL-GP (−0.34±0.16) (p<0.05). The present results do not support the hypothesis that Cr loading increases muscle glycogen storage.
Resumen
El principal objetivo de este estudio fue examinar la hipótesis que la suplementación con creatina (Cr) aumenta la concentración de glucógeno intramiocelular en humanos durante un periodo de ingesta elevada de hídratos de carbono. Veinte hombres entrenados fueron asignados de manera randomizada a dietas suplementadas diariamente con 252 g de polímeros de glucosa (GP) y bien 21 g de Cr (CR-GP, n=10) o placebo (PL-GP, n=10) durante 5 días. Los cambios en los níveles de glucógeno intramiocelular, y fosfocreatina (PCr) y ATP fueron determinados en reposo con Espectroscopía de Resonancia Magnética (13C-and31PMRS, respectivamente). Despues de CR-GP, Los níveles de glucógeno incrementaron desde 147±13 (error standard) mmol·(kg peso húmedo−1) a 172±13 mmol·(kg peso húmedo1), mientras incrementó desde 134±17 mmol·(kg peso húmedo−1) a 182±17 mmol·(kg peso húmedo−1) despues de PL-GP; los incrementos en la concentración de glucógeno intramiocelular en CR-GP y PL-GP no fueron estadisticamente diferentes. El incremento en el cociente PCr/ATP después de CR-GP (+0.20±0.12) fue estadisticamente diferente comparado con el cambio después de PL-GP (−0.34±0.16) (p<0.05). Los resultados no apoyan la hipótesis de que la creatina incrementa la concentración de glucógeno intramiocelular.
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Rico-Sanz, J., Zehnder, M., Buchli, R. et al. Creatine feeding does not enhance intramyocellular glycogen concentration during carbohydrate loading: an in vivo study by31P-and13C-MRS. J Physiol Biochem 64, 189–196 (2008). https://doi.org/10.1007/BF03178841
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DOI: https://doi.org/10.1007/BF03178841