Chemotherapy of malaria

Summary

To trace the antimalarial activity in the thiazole compounds, twenty-one thiazole derivatives of general formula I have been synthesised by the standard method of reacting the corresponding thiourea derivatives with chloracetal, chloracetone and ethyla-chloracetoacetate respectively. The guaridino compound of formula II could not be prepared by the action ofp-chlorophenylcyanamide on thiourea or by the action of desulphurising agents on a mixture ofp-chlorophenylthiourea and 2-aminothiazole.p-Chlorophenylguanidinothioformamide (IV) could not be prepared by the action of hydrogen sulphide onp-chlorophenyldicyandiamide.p-Chlorophenylisothiocyanate reacted with 2-aminothiazole to furnish 2-(p-chlorophenylthiocarbamido) thiazole (V) which on treatment with mercuric oxide in alcoholic ammonia solution furnished the guanidinothiazole derivative (II).