Summary
The simpler methoxy flavones and some of the corresponding hydroxy compounds are markedly toxic to fish. This definitely establishes that the pyrone ring containing the atom grouping II is a toxophore.
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References
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Sreerama Murti, V.V., Subba Rao, N.V. & Seshadri, T.R. Insecticidal properties and chemical constitution. Proc. Indian Acad. Sci. (Math. Sci.) 25, 22–24 (1947). https://doi.org/10.1007/BF03172540
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DOI: https://doi.org/10.1007/BF03172540