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Correlation of Her-2/Neu detection and angiogenesis in breast cancer — Proposed role in micrometastatic progression

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Conclusion

Overexpression/amplificatio n of Her-2/Neu increases angiogenesis in breast cancer. Her-2/Neu amplification is seen in bone marrow micrometastatic cells and correlates with Her-2/Neu amplification in primary tumour. The proangiogenic effect of Her2/Neu may represent metastatic progression in bone marrow micrometastases and may therefore be a potential target for the treatment of micrometastatic disease.

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Authors and Affiliations

  1. Department of Surgery and National Breast Cancer Research Institute, University College Hospital, Galway, Ireland

    S. Tormey, C. Curran & H. F. Given

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  1. S. Tormey
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  2. C. Curran
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  3. H. F. Given
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Tormey, S., Curran, C. & Given, H.F. Correlation of Her-2/Neu detection and angiogenesis in breast cancer — Proposed role in micrometastatic progression. Ir J Med Sci 171 (Suppl 1), 19 (2002). https://doi.org/10.1007/BF03170361

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  • DOI: https://doi.org/10.1007/BF03170361

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