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Hypertonic saline attenuates adenocarcinoma β-1 integrin expression by sodium-dependent induction of cytoskeletal rearrangement

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Conclusions

HTS significantly attenuates adenocarcinoma adhesion molecule expression by inducing conformational changes in the cytoskeleton. The failure of non-ionic and ionic sodiumfree hypertonic solutions to engender a decline in adhesion molecule expression suggests a pivotal role for sodium in the determination of the cellular response to electrical perturbation by hypertonic saline solutions.

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Authors and Affiliations

  1. Department of Surgery, Cork University Hospital, Ireland

    C. J. Shields, D. C. Winter, J. H. Wang, W. O. Kirwan & H. P. Redmond

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  1. C. J. Shields
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  2. D. C. Winter
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  3. J. H. Wang
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  4. W. O. Kirwan
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  5. H. P. Redmond
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Shields, C.J., Winter, D.C., Wang, J.H. et al. Hypertonic saline attenuates adenocarcinoma β-1 integrin expression by sodium-dependent induction of cytoskeletal rearrangement. Ir J Med Sci 171 (Suppl 4), 3 (2002). https://doi.org/10.1007/BF03170217

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  • DOI: https://doi.org/10.1007/BF03170217

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