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Olfactory function in people with genetic risk of dementia

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Abstract

Background

Screening for sensorial impairment is a secondary objective in the context of neurodegenerative diseases, including dementias. For example, olfactory dysfunction is among the first signs of Alzheimer’s disease. There has been no study of olfactory function in Irish subjects at risk of dementia.

Aim

To investigate olfactory function in non-demented Irish persons, who carry genetic risk factors for dementia.

Methods

Thirty-eight Irish adult subjects, who are at risk of dementia, were recruited. Cognitive performance and olfactory function were assessed and apolipoprotein E (APOE) genotype determined.

Results

Three and six subjects had a Mini Mental State Examination (MMSE) and Brief Smell Identification Test (B-SIT) score, respectively, outside the normal range. While five out of the fifteen ε-4 allele positive subjects had B-SIT scores outside the normal range, only one out of the twenty-three ε-4 allele negative subjects had; the difference in this frequency was significant (P=0.025). There was no significant difference (P=0.266) in the frequency of abnormal MMSE scores between ε-4 allele groups.

Conclusion

Further investigation is required to explore the reasons for the higher prevalence of olfactory dysfunction in ε-4 allele positive subjects.

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References

  1. Katzman R. Alzheimer’s disease.N. Engl. J. Med. 1986; 314: 964–973.

    Article  CAS  PubMed  Google Scholar 

  2. Ritchie K, Lovestone S. The dementias.Lancet 2002; 360: 1759–1766.

    Article  PubMed  Google Scholar 

  3. Souder E, Chastain JR, Williams RD. Dementia in the new millennium.Medsurg. Nurs. 2002; 11: 61–69.

    PubMed  Google Scholar 

  4. van Duijn CM, Hofman A. Risk factors for Alzheimer’s disease: the EURODEM collaborative re-analysis of case-control studies.Neuroepidemiology 1992; 11: 106–113.

    Article  PubMed  Google Scholar 

  5. McDowell I. Alzheimer’s disease: insights from epidemiologyAging (Milano) 2001; 13: 143–162.

    CAS  Google Scholar 

  6. Folstein MF, Folstein SE, McHugh PR. “Mini-Mental State.” A practical method for grading the cognitive state of patients for the clinician.J Psychiatr Res 1975; 12: 189–198.

    Article  CAS  PubMed  Google Scholar 

  7. Ercoli LM, Siddarth P, Dunkin JJ et al. MMSE Items predict cognitive decline in persons with genetic risk for Alzheimer’s disease.J Geriatr Psychiatry Neurol 2003; 16: 67–73.

    Article  PubMed  Google Scholar 

  8. Juva K, Verkkoniemi A, Viramo P et al. APOE epsilon 4 does not predict mortality, cognitive decline, or dementia in the oldest old.Neurology 2000; 54: 412–415.

    CAS  PubMed  Google Scholar 

  9. Nores JM, Biacabe B, Bonfils P. Olfactory disorders in Alzheimer’s disease and Parkinson’s disease. Review of the literature.Ann Med Interne 2000; 151 (2): 97–106.

    CAS  Google Scholar 

  10. Swan GE, Carmelli D. Impaired olfaction predicts cognitive decline in non-demented older adults.Neuroepidemiology 2002; 21(2): 58–67.

    Article  PubMed  Google Scholar 

  11. Devanand DP, Michaels-Marston KS, Liu X et al. Olfactory deficits in patients with mild cognitive impairment predict Alzheimer’s disease at follow-up.Am J Psychiatry 2000; 157(9): 1399–405.

    Article  CAS  PubMed  Google Scholar 

  12. Schiffman SS, Clark CM, Warwick ZS. Gustatory and olfactory dysfunction in dementia: not specific to Alzheimer’s disease.Neurobiol Aging 1990; 11(6) 597–600.

    Article  CAS  PubMed  Google Scholar 

  13. Wang QS, Tian L, Huang YL et al. Olfactory identification and apolipoprotein E e4 allele in mild cognitive impairment.Brain Research 2002; 951: 77–81.

    Article  CAS  PubMed  Google Scholar 

  14. Murphy C. Loss of olfactory function in dementing disease.Physiology & Behaviour 1999; 66(2): 177–182.

    Article  CAS  Google Scholar 

  15. Sheehan D, Bennett T, Cashman KD. Apolipoprotein E polymorphisms and serum cholesterol in healthy Irish adults: a proposed genetic marker for coronary artery disease riskIr J Med Sci 2000; 169: 50–54.

    Article  CAS  PubMed  Google Scholar 

  16. Crum RM, Anthony JC, Bassett SS, Folstein MF. Population-based norms for the Mini-Mental State Examination by age and educational level.JAMA 1993 May 12;269(18): 2386–91.

    Article  CAS  PubMed  Google Scholar 

  17. Doty RL, Marcus A, Lee W. Development of the 12-item Cross-Cuitural Smell Identification Test (CC-SIT).Laryngoscope 1996; 106: 353–356.

    Article  CAS  PubMed  Google Scholar 

  18. Burns A. Might olfactory dysfunction be a marker of early Alzheimer’s disease?Lancet 2000, January 8; vol 355

  19. Lomholt RK, Jurgensen KS. The mini-mental state examination in screening of cognitive dysfunction and dementia.Ugeskr-Laeger 1998; 160(50). 7251–4.

    CAS  PubMed  Google Scholar 

  20. Poirier J, Davignon J, Bouthillier D et al. Apolipoprotein E polymorphism and Alzheimer’s disease.Lancet 1993; 342: 697–699.

    Article  CAS  PubMed  Google Scholar 

  21. Jordan BD, Kanik AB, Horwich MS et al. Apolipoprotein E epsilon 4 and fatal cerebral amyloid angiopathy associated with dementia pugilistica,Ann Neurol. 1995 38: 698–9

    Article  CAS  PubMed  Google Scholar 

  22. Frisoni GB, Calabresi L, Geroldi C, Bianchetti A, D’Acquarica AL, Govoni S, Sirtori CR, Trabucchi M, Franceschini G. Apolipoprotein E epsilon 4 allele in Alzheimer’s disease and vascular dementia. Dementia. 1994; 5: 240–2.

    CAS  PubMed  Google Scholar 

  23. Rodriguez Martin T, Calella AM, Silva S, Munna E, Modena P, Chiesa R, Terrevazzi S, Ruggieri RM, Palermo R, Piccoli F, Confalonieri R, Tiraboschi P, Fragiacomo C, Quadri P, Lucca U, Forloni G. Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer’s disease and vascular dementia. Dement Geriatr Cogn Disord. 2000; 11: 239–44.

    Article  Google Scholar 

  24. Engelborghs S, Dermaut B, Goeman J et al. Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects.J Neurol Neurosurg Psychiatry. 2003; 74: 1148–51.

    Article  CAS  PubMed  Google Scholar 

  25. Wilson RS, Schneider JA, Barnes LL et al. The apolipoprotein E-4 allele and decline in different cognitive systems during a 6-year period.Arch Neurol 2002; 59: 1154–1160.

    Article  PubMed  Google Scholar 

  26. Reiman EM, Caseili RJ, Yun LS et al. Preclinical evidence of Alzheimer’s disease in person homozygous for the e4 allele for apolipoprotein E.N Engl J Med 1995; 343: 449–456.

    Google Scholar 

  27. Reed T, Carmelii D, Swan GE et al. Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E4 allele.Arch Neurol 1994; 51: 1189–1192.

    CAS  PubMed  Google Scholar 

  28. Berr C, Dufouil C, Brousseau T et al. Early effect of ApoE4 allele on cognitive results in a group of highly performing subjects: the EVA study.Neurosci Lett 1996; 218: 9–12.

    Article  CAS  PubMed  Google Scholar 

  29. Tilvis RS, Strandberg TE, Juva K. Apolipoprotein E phenotypes, dementia and mortality in a prospective population sample.J Am Cer Soc 1998; 46: 712–715

    CAS  Google Scholar 

  30. Bondi MW, Salmon DP, Monsch AU et al. Episodic memory changes are associated with the APOE-4 allele in non-demented older adults.Neurology 1995; 45: 2203–2207.

    CAS  PubMed  Google Scholar 

  31. Doty RL. Olfactory capacities in aging and Alzheimer’s disease. Psychophysical and anatomic considerations.Ann NY Acad Sci 1991; 640: 20–7.

    CAS  PubMed  Google Scholar 

  32. Rocca WA, Hofman A, Brayne C, Breteler MM, Clarke M, Copeland JR, Dartigues JF, Engedal K, Hagnell O, Heeren TJ, et al. The prevalence of vascular dementia in Europe: facts and fragments from 1980–1990 studies. EURODEM-Prevalence Research Group. Ann Neurol. 1991 Dec;30(6): 817–24.

    Article  CAS  PubMed  Google Scholar 

  33. Nathan BP, Yost J, Litherland MT, Struble RG, Switzer PV. Olfactory function in apoE knockout mice. Behavioural Brain Research 150 (2004) 1–7.

    Article  CAS  PubMed  Google Scholar 

  34. Nathan BP, Nisar R, Beckman-Randall S, Short J, Sherrow M, Struble RG. Role of apoE in olfactory nerve regeneration in mice. Soc Neurosci 2000;26 (abstract).

  35. Struble RG, Short J, Ghobrial M, Nathan BP. Apolipoprotein E immunoreactivity in human and mouse olfactory bulb. Neurosci Lett 1999;267: 137–40.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Food and Nutritional Sciences, University College Cork, Cork

    R. Salerno-Kennedy, S. Cusack & K. D. Cashman

  2. Dept of Medicine, University College, Cork

    R. Salerno-Kennedy & K. D. Cashman

Authors
  1. R. Salerno-Kennedy
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  2. S. Cusack
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  3. K. D. Cashman
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Correspondence to R. Salerno-Kennedy.

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Salerno-Kennedy, R., Cusack, S. & Cashman, K.D. Olfactory function in people with genetic risk of dementia. Ir J Med Sci 174, 46–50 (2005). https://doi.org/10.1007/BF03168982

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