Skip to main content

Correlation between birth weight, leptin, zinc and copper levels in maternal and cord blood

Correlación entre peso del recién nacido y niveles de leptina, zinc y cobre en sangre materna y del cordón umbilical

Journal of Physiology and Biochemistry volume 63, pages 121–128 (2007)Cite this article

Abstract

Leptin and zinc are involved in the regulation of appetite. Copper is a trace element regulating the functions of several cuproenzymes that are essential for life. To evaluate the relationship between zinc and copper status and the leptin system in humans, we examined whether leptin concentrations in the mother and the newborn correlate with the weight of mother, placenta and newborn. A total of 88 pregnant women at 38–42 weeks’ gestation were studied. All infants were categorized as small for gestational age (SGA) (n=16), average for gestational age (AGA) (n=59) or large for gestational age (LGA) (n=13). Leptin, zinc, and copper levels were measured in maternal and cord serum at birth. Maternal BMI and placental weight of the LGA groups were significantly higher than those of the SGA and AGA groups. Cord and maternal leptin levels of the SGA groups were significantly lower than those of the AGA and LGA groups. Maternal serum leptin levels were positively correlated with BMI and maternal zinc levels in all groups. Cord serum leptin levels of all groups were positively correlated with birth weight and placental weight. Birth weight was negatively correlated with maternal and cord copper level of all groups. Umbilical leptin concentrations of SGA newborns correlated with leptin concentrations of their mothers. In all pregnancies, birth weight increases in association with increase in cord leptin level. Our results suggest that maternal zinc but not copper level has an effect on maternal serum leptin levels. The increase in copper level in both maternal and cord blood may contribute to restriction in fetal growth.

Resumen

La leptina y el zinc están implicados en la regulación del apetito. El cobre es un oligoelemento que regula las funciones de varios cuproenzimas esenciales para la vida. Para evaluar la relación entre los niveles de zinc, cobre y leptina en los humanos, se estudió en embarazos a término si la concentración de leptina, zinc y cobre en la madre y el recién nacido se correlacionaba con el peso materno, el de la placenta y del recién nacido. Se estudiaron 88 mujeres gestantes de 38–42 semanas y se agruparon según el peso al nacer de los recién nacidos en pequeños (P) para la edad gestacional (n=16), medianos (M; n=59) y grandes (G; n=13). Se determinaron los niveles de leptina, zinc y cobre en la sangre materna y en la del cordón umbilical al nacimiento. El índice de masa corporal (BMI) materoo y el peso de la placenta correspondiente al grupo G fueron significativamente mayores que en los otros grupos y los niveles de leptina maternos y del cordón fueron significativamente menores en el grupo P. Los niveles séricos maternos de leptina se correlacionaron positivamente con los valores maternos de zinc y el del BMI en todos los grupos. Los niveles de leptina en la sangre del cordón se correlacionaron positivamente con el peso de la placenta y del recién nacido en todos los grupos. El peso al nacimiento secorrelacionó negativamente con el nivel de cobre en sangre materna y la del cordón de todos los grupos. Las concentraciones umbilicales de leptina en el grupo P se correlacionaron con las de la correspondiente sangre materna. En todos los embarazos, el peso del recién nacido aumentó en relación con el incremento de la concentración umbilical de leptina. Los resultados sugieren que el zinc materno, no el cobre, influye sobre el nivel de leptina materna y que el nivel de cobre en sangre materna y umbilical podría contribuir a la restricción del peso fetal.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. Apte, S.V., and Iyengar, L. (1972): Br. J. Nutr., 27, 305–312.

    Article  CAS  PubMed  Google Scholar 

  2. Atanassova, P., and Popova, L. (2000): Cells Tissues Organs., 166, 15–19.

    Article  CAS  PubMed  Google Scholar 

  3. Auwerx, J., and Staels, B. (1998): Lancet, 351, 737–742.

    Article  CAS  PubMed  Google Scholar 

  4. Blum, W.F., Englaro, P., Hanitsch, S., Juul, A., Hertel, N.T., Muller, J., Skakkebaek, N.E., Heiman, M.L., Birkett, M., Attanasio, A.M., Kiess, W., and Rascher, W. (1997): J. Clin. Endocrinol. Metab., 82, 2904–2910.

    Article  CAS  PubMed  Google Scholar 

  5. Buamah, P.H., Russell, M., Milford-Ward, A., Taylor, P., and Roberts, D.F. (1984): Clin. Chem., 30, 1667–1670.

    Google Scholar 

  6. Cetin, I., Morpurgo, P.S., Radaelli, T., Taricco, E., Cortelazzi, D., Bellotti, M., Pardi, G., and Beck-Peccoz, P. (2000): Pediatr. Res., 48, 646–651.

    Article  CAS  PubMed  Google Scholar 

  7. Chen, M.D., Lin, P.Y., and Sheu, W.H. (1997): Biol. Trace Elem. Res., 60, 123–129.

    Article  CAS  PubMed  Google Scholar 

  8. Chen, M.D., Song, Y.M., and Lin, P.Y. (2000): Horm. Metab. Res., 32, 107–109.

    Article  CAS  PubMed  Google Scholar 

  9. Chen, M.D., Song, Y.M., and Lin, P.Y. (2000): Life Sci., 66, 2143–2149.

    Article  CAS  PubMed  Google Scholar 

  10. Coleman, J.E. (1992): Annu. Rev. Biochem., 61, 897–946.

    Article  CAS  PubMed  Google Scholar 

  11. Considine, R.V., Sinha, M.K., Heiman, M.L., Kriauciunas, A., Stephens, T.W., Nyce, M.R., Ohannesian, J.P., Marco, C.C., McKee, L.J., and Bauer, T.L. (1996): N. Engl. J. Med., 334, 292–295.

    Article  CAS  PubMed  Google Scholar 

  12. Frendo, J.L., Therond, P., Bird, T., Massin, N., Muller, F., Guibourdenche, J., Luton, D., Vidaud, M., Anderson, W.B., and Evain-Brion, D. (2001): Endocrinology, 142, 3638–3648.

    Article  CAS  PubMed  Google Scholar 

  13. Gluckman, P.D., and Heymann, M.A. (1996): In “Scientific Basis of Pediatric and Perinatal Medicine”, Edward Arnold Publisher, London, pp. 290–297.

    Google Scholar 

  14. Hassink, S.G., de Lancey, E., Sheslow, D.V., Smith-Kirwin, S.M., O’Connor, D.M., Considine, R.V., Opentanova, I., Dostal, K., Spear, M.L., Leef, K., Ash, M., Spitzer, A.R., and Funanage, V.L. (1997): Pediatrics, 100 (1), E1.

    Article  CAS  PubMed  Google Scholar 

  15. Hytinantti, T., Koistinen, H.A., Koivisto, V.A., Karonen, S.L., Rutanen, E.M., and Andersson, S. (2000): Arch. Dis. Child. Fetal Neonatal Ed., 83, F13-F16.

    Article  CAS  PubMed  Google Scholar 

  16. Jaquet, D., Leger, J., Levy-Marchal, C., Oury, J.F., and Czernichow, P. (1998): J. Clin. Endocrinol. Metab., 83, 1243–1246.

    Article  CAS  PubMed  Google Scholar 

  17. Laml, T., Hartmann, B.W., Ruecklinger, E., Preyer, O., Soeregi, G., and Wagenbichler, P.J. (2001): Soc. Gynecol. Investig., 8, 43–47.

    Article  CAS  Google Scholar 

  18. Manderson, J.G., Patterson, C.C., Hadden, D.R., Traub, A.I., Leslie, H., and McCance, D.R. (2003): Am. J. Obstet. Gynecol., 188, 1326–1332.

    Article  CAS  PubMed  Google Scholar 

  19. Mangian, H.F., Paul, G.L., and Shay, N.F. (1997): Faseb, 11 (3), A1124.

    Google Scholar 

  20. Mantzoros, C.S., Prasad, A.S., Beck, F.W., Grabowski, S., Kaplan, J., Adair, C., and Brewer, G.J. (1998): J. Am. Coll. Nutr., 17, 270–275.

    CAS  PubMed  Google Scholar 

  21. Mantzoros, C.S., Varvarigou, A., Kaklamani, V.G, Beratis, N.G., and Flier, J.S. (1997): J. Clin. Endocrinol. Metab., 82, 2856–2861.

    Article  CAS  PubMed  Google Scholar 

  22. Olivares, M., and Uauy, R. (1996): Am. J. Clin. Nutr., 63, 791–796.

    Google Scholar 

  23. Olusi, S., Al-Awadhi, A., Abiaka, C., Abraham, M., and George, S. (2003): Biol. Trace Elem. Res., 91, 137–144.

    Article  CAS  PubMed  Google Scholar 

  24. Pelleymounter, M.A., Cullen, M.J., Baker, M.B., Hecht, R., Winters, D., Boone, T., and Collins, F. (1995): Science, 269, 540–543.

    Article  CAS  PubMed  Google Scholar 

  25. Pidoux, G., Guibourdenche, J., Frendo, J.L., Gerbaud, P., Conti, M., Luton, D., Muller, F., and Evain-Brion, D. (2004): Placenta, 25, S79-S84.

    Article  CAS  PubMed  Google Scholar 

  26. Prasad, AS. (1996): Ann. Intern. Med., 125, 142–144.

    CAS  PubMed  Google Scholar 

  27. Schubring, C., Englaro, P., Siebler, T., Blum, W.F., Demirakca, T., Kratzsch, J., and Kiess, W. (1998): Horm. Res., 50, 276–283.

    Article  CAS  PubMed  Google Scholar 

  28. Schubring, C., Kiess, W., Englaro, P., Rascher, W., Dotsch, J., Hanitsch, S., Attanasio, A., and Blum, W.F. (1997): J. Clin. Endocrinol. Metab., 82, 1480–1483.

    Article  CAS  PubMed  Google Scholar 

  29. Shekhawat, P.S., Garland, J.S., Shivpuri, C., Mick, G.J., Sasidharan, P., Pelz, C.J., and McCormick, K.L. (1998): Pediatr. Res., 43, 338–343.

    Article  CAS  PubMed  Google Scholar 

  30. Stanner, S., and Smith, E. (2005): British Nutrition Foundation Nutrition Bulletin, 30, 94–102.

    Google Scholar 

  31. Tamura, T., Goldenberg, R.L., Johnston, K.E., and Cliver, S.P. (1998): Obstet. Gynecol., 91, 389–395.

    Article  CAS  PubMed  Google Scholar 

  32. Varvarigou, A., Mantzoros, C.S., and Beratis, N.G. (1999): Clin. Endocrinol., 50, 177–183.

    Article  CAS  Google Scholar 

  33. Yildiz, L., Avci, B., and Ingec, M. (2002): Clin. Chem. Lab. Med., 40, 14–17.

    Google Scholar 

  34. Zamorano, P.L., Mahesh, V.B., De Sevilla, L.M., Chorich, L.P., Bhat, G.K., and Brann, DW. (1998): Neuroendocrinology, 65, 223–228.

    Article  Google Scholar 

  35. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J.M. (1994): Nature, 372, 425–432.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Affiliations

  1. Department of Biochemistry, Sivas State Hospital, TR-58140, Sivas, Turkey

    U. Ozdemir

  2. Department of Physiology, Cumhuriyet University School of Medicine, TR-58140, Sivas, Turkey

    S. Gulturk

  3. Department of Biochemistry, Cumhuriyet University School of Medicine, TR-58140, Sivas, Turkey

    A. Aker

  4. Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, TR-58140, Sivas, Turkey

    T. Guvenal & G. Imir

  5. Department of Nuclear Medicine, Cumhuriyet University School of Medicine, TR-58140, Sivas, Turkey

    T. Erselcan

Authors
  1. U. Ozdemir
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Gulturk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Aker
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Guvenal
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Imir
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T. Erselcan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Gulturk.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ozdemir, U., Gulturk, S., Aker, A. et al. Correlation between birth weight, leptin, zinc and copper levels in maternal and cord blood. J. Physiol. Biochem. 63, 121–128 (2007). https://doi.org/10.1007/BF03168223

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03168223

Key words

  • Leptin
  • Birth weight
  • Zinc
  • Copper

Palabras clave

  • Leptina
  • Zinc
  • Cobre
  • Peso al nacer