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Shape analysis of hippocampal surface structure in patients with unilateral mesial temporal sclerosis

  • SESSION 1B: Image Processing
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Abstract

Structural hippocampal magnetic resonance (MR) imaging-based analysis is helpful in the diagnosis and treatment of mesial temporal epileptic seizures. Computational anatomic techniques provide a framework for objective assessment of three-dimensional hippocampal structure. We applied a previously validated technique of deformation-based hippocampal segmentations in 20 subjects with documented unilateral mesial temporal sclerosis (MTS) and temporal lobe epilepsy. Using composite images, we then measured shape differences between the epileptogenic, smaller hippocampus, and contralateral hippocampus. Final shape differences were projected on the contralateral “normal” side. We calculated results for the left MTS group (10 patients) and right MTS group (10 patients) separately. Both groups showed similar regions of maximal inward deformation in the affected hippocampus, which were the medical and lateral aspect of the head, and posterior aspect of the tail. These results suggest that there are specific three-dimensional patterns of volume loss in patients with mesial temporal epilepsy.

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Authors and Affiliations

  1. Department of Neurology and Division of Neurosurgery, Saint Louis University, 3635 Vista Ave, 63110, St. Louis, MO

    R. Edward Hogan MD, Richard D. Bucholz, Indrajit Choudhuri, Kevin E. Mark, Chris S. Butler & Sarang Joshi

  2. IntellX, Broomfield, CO

    R. Edward Hogan MD, Richard D. Bucholz, Indrajit Choudhuri, Kevin E. Mark, Chris S. Butler & Sarang Joshi

Authors
  1. R. Edward Hogan MD
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  2. Richard D. Bucholz
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  3. Indrajit Choudhuri
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  4. Kevin E. Mark
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  5. Chris S. Butler
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  6. Sarang Joshi
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Correspondence to R. Edward Hogan MD.

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Hogan, R.E., Bucholz, R.D., Choudhuri, I. et al. Shape analysis of hippocampal surface structure in patients with unilateral mesial temporal sclerosis. J Digit Imaging 13 (Suppl 1), 39–42 (2000). https://doi.org/10.1007/BF03167621

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  • DOI: https://doi.org/10.1007/BF03167621

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