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A localization method for the measurement of fast relaxing13C NMR signals in humans at high magnetic fields

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Abstract

Nuclear magnetic resonance (NMR) signals with shortT 1 andT 2, such as the13C signal of glycogen, are difficult to localize in three dimensions without major signal loss. A pulse sequence that accomplishes the spatial localization of1H-decoupled13C NMR signals on a whole-body scanner within the Food and Drug Administration guidelines for specific absorption rates was designed. The method uses an optimized three-dimensional outer volume suppression scheme combined with one-dimensional image-selected in vivo spectroscopy and surface coil detection. The localization performance of the sequence was validated at 4 T with double chambered phantoms and13C magnetic resonance imaging. Localized13C spectra were acquired from human brain and muscle.

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Authors and Affiliations

  1. Center for Magnetic Resonance Research, University of Minnesota, 2021 6th Street SE, 55455, Minneapolis, Minnesota, USA

    G. Öz, P. G. Henry, I. Tkáĉ & R. Gruetter

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  1. G. Öz
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  2. P. G. Henry
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  3. I. Tkáĉ
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  4. R. Gruetter
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Öz, G., Henry, P.G., Tkáĉ, I. et al. A localization method for the measurement of fast relaxing13C NMR signals in humans at high magnetic fields. Appl. Magn. Reson. 29, 159–169 (2005). https://doi.org/10.1007/BF03166961

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  • DOI: https://doi.org/10.1007/BF03166961

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