Abstract
T1 in the rotating frame (T1ρ) has been recently shown to be an early magnetic resonance imaging index of ongoing pathology in vivo. Dispersion ofT1ρ at aB1 range from 620 to 160500 rad/s was quantified in the rat brain to study the effects of ischaemia onT1ρ relaxation and to elude the role of physico-chemical mechanisms underlying the relaxation changes. The results show a biphasic effect of the dispersion ofR1ρ (1/T1ρ) in ischaemic brain. In the lowB1 region (less than 5000 rad/s), an increase was detected, while at the highB1 end of the experiments,R1ρ was reduced. This was accompanied by a change in the fitted values describing the dispersion characteristics. Injection of a superparamagnetic contrast agent, AMI-227, before ischaemia shifted theR1ρ curve upwards by 4% but showed no effect on the shape of theR1ρ dispersion curve. The present results argue for a specific effect of endogenous susceptibility on cerebralR1ρ in the early moments of ischaemia due to a relaxation enhancement in the blood pool. Our results confirm that quantitativeR1ρ dispersion nuclear magnetic resonance (NMR) improves the sensitivity ofR1ρ NMR to detect ischaemia in vivo. Simple empirical linear or exponential fits proved to be efficient ways to describe dispersion data in the limitedB1 range, as more detailed models may not offer additional information in a physically relevant manner for complex systems, such as the brain.
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Kettunen, M.I., Kauppinen, R.A. & Gröhn, O.H.J. Dispersion of cerebral on-resonanceT 1 in the rotating frame (T 1ρ) in global ischaemia. Appl. Magn. Reson. 29, 89–106 (2005). https://doi.org/10.1007/BF03166957
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DOI: https://doi.org/10.1007/BF03166957