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Effects of resveratrol and its analogs on scavenging hydroxyl radicals: Evaluation by EPR spin trapping method

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Abstract

Resveratrol (3,4′,5-trihydroxy-trans-stilbene) and six analogs, polyhydroxystilbenes, were synthesized. Their effects on scavenging hydroxyl radicals were studied by electron paramagnetic resonance (EPR) spin trapping method. The EPR signal intensity of the spin adduct of hydroxyl radical to 5,5-dimethyl-1-pyrroline N-oxide was detected and used as a standard for the evaluation of the effect of the seven compounds on scavenging hydroxyl radicals. While all seven compounds exhibited hydroxyl radical-scavenging activity, some of them proved to be more effective than resveratrol in this model. Another stable but low-intensity spin adduct was also observed by EPR. A possible assignment is proposed.

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  1. National Laboratory of Applied Organic Chemistry, Lanzhou University, 298 Tianshui Rd., 730000, Lanzhou, People’s Republic of China

    M. Lu, J. -G. Fang, Z. -L. Liu & L. -M. Wu

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  1. M. Lu
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  2. J. -G. Fang
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  3. Z. -L. Liu
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  4. L. -M. Wu
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Lu, M., Fang, J.G., Liu, Z.L. et al. Effects of resveratrol and its analogs on scavenging hydroxyl radicals: Evaluation by EPR spin trapping method. Appl. Magn. Reson. 22, 475–481 (2002). https://doi.org/10.1007/BF03166127

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  • DOI: https://doi.org/10.1007/BF03166127

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