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A brain uptake study of [1-11C]hexanoate in the mouse: The effect of hypoxia, starvation and substrate competition

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Abstract

We evaluated the potential of sodium [1-11C]hexanoate (11C-HA) as a radiopharmaceutical with which to assess oxidative metabolism of the brain by PET.11C-HA, sodium [1-14C]acetate and [3H]deoxyglucose were simultaneously injected into mice under control, hypoxic and starving conditions. In the control, the brain uptake of11C was maximal at 3 min (% ID/g = 2.2–2.5), being twice as high as that of14C, followed by a gradual clearance. The time-radioactivity curve of11C was similar to that of14C. Hypoxia enhanced the brain uptake of3H, but not of either11C or14C. Starvation enhanced the brain uptake of3H and11C. The clearance rate of11C was not significantly affected by either condition. In the control brain at 3 min postinjection of HA, 65% of the total radioactivity was detected as labeled glutamate and glutamine, which was gradually decreased by 47% at 30 min. The brain to blood ratios of11C-HA at 3 min were significantly reduced by butyrate, hexanoate and octanoate loading but not by that with other monocarboxylic acids or ketone bodies.

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Authors and Affiliations

  1. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1 Nakacho, Itabashi, 173, Tokyo, Japan

    Kiichi Ishiwata, Kenji Ishii & Michio Senda

  2. Faculty of Hygienic Sciences, Kitasato University, Japan

    Koji Ogawa & Tadashi Nozaki

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  1. Kiichi Ishiwata
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  2. Kenji Ishii
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  3. Koji Ogawa
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  4. Tadashi Nozaki
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  5. Michio Senda
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Ishiwata, K., Ishii, K., Ogawa, K. et al. A brain uptake study of [1-11C]hexanoate in the mouse: The effect of hypoxia, starvation and substrate competition. Ann Nucl Med 10, 265–270 (1996). https://doi.org/10.1007/BF03165404

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  • DOI: https://doi.org/10.1007/BF03165404

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