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Myocardial defect detected by123I-BMIPP scintigraphy and left ventricular dysfunction in patients with idiopathic dilated cardiomyopathy

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Abstract

The present study examined the role of myocardial fatty acid in patients with idiopathic cardiomyopathy (DCM) by means of123I-β-methyl-p-iodophenyl pentadecanoic acid (123I-BMIPP) scintigraphy. Thirteen patients underwent123I-BMIPP imaging,201Tl imaging and echocardiography. All patients showed defective myocardial uptake of123I-BMIPP and201Tl. The left ventricular end-diastolic dimension (64.1 ± 7.3 mm vs. 55.6 ± 1.5 mm, p < 0.05) and end-systolic dimension (52.4 ± 8.0 mm vs. 40.6 ± 2.1 mm, p < 0.01) were significantly larger in the large defect group (123I-BMIPP defect score (DS) > 8) than the small defect group (DS < 7). The % fractional shortening (%FS) was also significantly smaller (18.6 ± 3.8% vs. 27.0 ± 3.3%, p < 0.01) in the large defect group. The123I-BMIPP DS correlated statistically with %FS (r = 0.75, p < 0.01), while the201Tl DS did not (r = 0.41, ns). We conclude that the patients with DCM revealed a123I-BMIPP uptake defect and the defect reflected the degree of left ventricular dysfunction.

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Authors and Affiliations

  1. First Department of Internal Medicine, Kobe University School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, 650, Kobe, Japan

    Yasunori Hashimoto, Hiroshi Yamabe & Mitsuhiro Yokoyama

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  1. Yasunori Hashimoto
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  2. Hiroshi Yamabe
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  3. Mitsuhiro Yokoyama
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Hashimoto, Y., Yamabe, H. & Yokoyama, M. Myocardial defect detected by123I-BMIPP scintigraphy and left ventricular dysfunction in patients with idiopathic dilated cardiomyopathy. Ann Nucl Med 10, 225–230 (1996). https://doi.org/10.1007/BF03165396

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  • DOI: https://doi.org/10.1007/BF03165396

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