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Limitation of infarct size with preconditioning and calcium antagonist (Diltiazem): Difference in99mTc-PYP uptake in the myocardium

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Abstract

Ischemic cell injury and the uptake mechanism of99mTc-PYP (Pyrophosphate) were studied with preconditioning and calcium antagonist. Method: The coronary artery of an adult mongrel dog was clamped for 1 hour, followed by reperfusion and99mTc-PYP injection. A control group (group C, n = 8), a group in which continuous drip infusion of diltiazem (10 mg/kg) (group D, n = 7), and a group preconditioned by six 5-minute clampings and perfusions before occlusion (group P, n = 6) were compared. Results: Wall motion was fully recovered in group D but not in group P after 2 hours of reperfusion. The99mTc-PYP uptake ratio showed a significant (p < 0.05) reduction in group D (11.5: 3.6 compared with group C), but not in group P (11.5: 9.1, p = 0.25). The infarct area was 1.2 ± 0.6% of the left ventricle in group D, 1.3 ± 0.4 in group P, and 6.4 ± 1.0 in group C (p < 0.01 in groups D and P vs. group C). Conclusions: These findings suggest that preconditioning does not alleviate stunning, but it improves cell injury in spite of high uptake of99mTc-PYP. Diltiazem protects from both stunning and cell injury, suggesting a different mechanism of myocardial protection from that of preconditioning.

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Authors and Affiliations

  1. Third Division, Department of Internal Medicine, Kyoto University Hospital, 54 Kawaracho, Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Kazumi Okuda, Ryuji Nohara, Motonari Ogino, Masatoshi Fujita & Shigetake Sasayama

  2. Department of Nuclear Medicine, Kyoto University Hospital, Japan

    Nagara Tamaki & Junji Konishi

Authors
  1. Kazumi Okuda
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  2. Ryuji Nohara
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  3. Motonari Ogino
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  4. Nagara Tamaki
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  5. Junji Konishi
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  6. Masatoshi Fujita
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  7. Shigetake Sasayama
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Okuda, K., Nohara, R., Ogino, M. et al. Limitation of infarct size with preconditioning and calcium antagonist (Diltiazem): Difference in99mTc-PYP uptake in the myocardium. Ann Nucl Med 10, 201–209 (1996). https://doi.org/10.1007/BF03165393

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  • DOI: https://doi.org/10.1007/BF03165393

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