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The measurement of blood flow parameters with deuterium stable isotope MR imaging

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Abstract

Methods

Because there are no radioactive hydrogen isotopes which can be used for clinical examinations, deuterium as a non-radioactive, freely diffusible tracer has some advantages compared with the radioactive tracers in the measurement of blood flow parameters. A non-invasive technique to estimate the mean tissue blood flow parameterin vivo was developed by using deuterium nuclear magnetic resonance (NMR) imaging in rat. We obtained the NMR signal changes from deuterium NMR images in nine male Wister rats after intravenous injection of D2O and applied exponential curve fitting analyses to calculate blood flow parameters of the brain, heart and skeletal muscle.

Results

While fitting the reducing of the monoexponential function yielded a blood flow parameter of 27.9 ± 1.6 ml/min/100 g tissue weight for the brain and 46.7 ± 3.7 ml/min/100 g tissue weight for the heart, fitting the early reducing of the signal intensity of the biexponential function yielded a blood flow parameter of 95.6 ± 10.9 ml/min/100 g tissue weight for the brain and 108.0 ±13.1 ml/min/100 g tissue weight for the heart. The mean muscle blood flow parameter determined by the monoexponential uptake function was 43.8 ± 7.3 mZ/min/100 g tissue weight. Conclusions: The blood flow parameter measurement by means of an imaging coil for deuterium is less invasive and reflects the mean tissue blood flow parameter for the entire tissue sample more homogeneously than spectroscopic monitoring.

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References

  1. Kim SG, Ackerman JJH. Quantitative determination of tumor blood flow and perfusion via deuterium nuclear magnetic resonance spectroscopy in mice.Cancer Res 48: 3449–3453, 1988.

    PubMed  CAS  Google Scholar 

  2. Corbett RJT, Laptook AR, Olivares E. Simultaneous measurement of cerebral blood flow and energy metabolites in piglets using deuterium and phosphorus nuclear magnetic resonance.J Cereb Blood Flow Metab 11: 55–65, 1991.

    PubMed  CAS  Google Scholar 

  3. Detre JA, Subramanian VH, Mitchell MD, Smith DS, Kobayashi A, Zaman A, et al. Measurement of regional cerebral blood flow in cat brain using intracarotid2H2O and2H NMR imaging.Magn Reson Med 14: 389–395, 1990.

    Article  PubMed  CAS  Google Scholar 

  4. Ackerman JJH, Ewy CS, Becker NN, Shalwitz RA. Deuterium nuclear magnetic resonance measurements of blood flow and tissue perfusion employing2H2O as a freely diffusible tracer.Proc Natl Acad Sci USA 84: 4099–4102, 1987.

    Article  PubMed  CAS  Google Scholar 

  5. Ackerman JJH, Ewy CS, Kim SG, Shalwitz RA. Deuterium magnetic resonancein vivo: The measurement of blood flow and tissue perfusion.Ann NY Acad Sci 508: 89–98, 1987

    Article  PubMed  CAS  Google Scholar 

  6. Mitchell MD, Osbakken M. Estimation of myocardial perfusion using deuterium nuclear magnetic resonance.Magn Reson Imaging 9: 545–552, 1991.

    Article  PubMed  CAS  Google Scholar 

  7. Kim SG, Ackerman JJH. Multicompartment analysis of blood flow and tissue perfusion employing D2O as a freely diffusible tracer: A nobel deuterium NMR technique demonstrated via application with murine RIF-1 tumors.Magn Reson Med 8: 410–426, 1988.

    Article  PubMed  CAS  Google Scholar 

  8. Kim SG, Ackerman JJH. Quantification of regional blood flow by monitoring of exogenous tracer via nuclear magnetic resonance spectroscopy.Mag Reson Med 14: 266–282, 1990.

    Article  CAS  Google Scholar 

  9. Ewy CS, Ackerman JJH, Balaban RS. Deuterium NMR cerebral imagingin situ.Magn Reson Med 8: 35–44, 1988.

    Article  PubMed  CAS  Google Scholar 

  10. Haining JL, Turner MD, Pantall RM. Local cerebral blood flow in young and old rats during hypoxia and hypercapnia.Am J Physiol 218: 1020–1024, 1970.

    PubMed  CAS  Google Scholar 

  11. Nilsson L, Siesjo BK. The effect of phenobalbitone anaesthesia on blood flow and oxygen consumption in the rat brain.Acta Anaesth Scand Supple 57: 18–24, 1975.

    Article  CAS  Google Scholar 

  12. Hayes CJ, Palmer JD. The suppression of mouse spontaneous locomotor activity by the ingestion of deuterium oxide.Experientia 32: 469–470, 1976.

    Article  PubMed  CAS  Google Scholar 

  13. Kanwar KC, Verma R. Oral D2O administration and enzymatic changes in rat testis.Acta Biol Med Ger 35: 577–581, 1976.

    PubMed  CAS  Google Scholar 

  14. Kanwar KC, Verma R. Biologic effects of orally administered deuterium oxide on rat liver.Exp Pathol 13: 255–261, 1977.

    CAS  Google Scholar 

  15. Brereton IM, Irving MG, Field J, Doddrell DM. Preliminary studies on the potential ofin vivo deuterium NMR spectroscopy.Biochem Biophys Res Commun 137: 579–584, 1986.

    Article  PubMed  CAS  Google Scholar 

  16. Mattiello J, Evelhoch JL. Relative volume-average murine tumor blood flow measurement via deuterium nuclear magnetic resonance spectroscopy.Magn Res Med 18: 320–334, 1991.

    Article  CAS  Google Scholar 

  17. Evelhoch JL, McDouall JBL, Mattiello J, Mattiello J, Simpson NE. Measurement of relative regional tumor blood flow in mice by deuterium NMR imaging.Magn Res Med 24: 42–52, 1992.

    Article  CAS  Google Scholar 

  18. Branch CA, Helpern JA, Ewing JR, Welch KMA.19F NMR imaging of cerebral blood flow.Magn Res Med 20: 151–157, 1991.

    Article  CAS  Google Scholar 

  19. Neil JJ. The validation of freely diffusible tracer methods with NMR detection for measurement of blood flow.Magn Res Med 19: 299–304, 1991.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Advanced Technology for Medical Imaging, Research Center of Charged Particle Technique, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, 263, Chiba, Japan

    Yoshimi Furuya, Hiroo Ikehira, Takayuki Obata, Masahisa Koga & Katsuya Yoshida

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  1. Yoshimi Furuya
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  2. Hiroo Ikehira
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  3. Takayuki Obata
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  4. Masahisa Koga
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  5. Katsuya Yoshida
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Correspondence to Hiroo Ikehira.

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Furuya, Y., Ikehira, H., Obata, T. et al. The measurement of blood flow parameters with deuterium stable isotope MR imaging. Ann Nucl Med 11, 281–284 (1997). https://doi.org/10.1007/BF03165294

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  • DOI: https://doi.org/10.1007/BF03165294

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