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Impaired myocardial fatty acid metabolism detected by123I-BMIPP in patients with unstable angina pectoris: Comparison with perfusion imaging by99mTc-sestamibi

Annals of Nuclear Medicine volume 9, pages 125–130 (1995)Cite this article

Abstract

The present study was undertaken to determine the potential diagnostic value of123I-BMIPP scintigraphy for the detection of altered myocardial fatty acid metabolism in patients with unstable angina. Both myocardial metabolic imaging with123I-BMIPP and perfusion imaging with99mTcsestamibi were performed at rest in 28 patients with unstable angina in the pain-free state. The regional uptakes of123I-BMIPP or99mTc-sestamibi were scored semiquantitatively (0 = normal, 4 = no activity) and compared with the coronary arteriographic findings. Decreased uptakes of123I-BMIPP were observed in 18 patients, and 11 patients had abnormal99mTc-sestamibi images. Defect scores of123I-BMIPP were larger than those of99mTc-sestamibi (7.8 ± 2.1 vs. 5.2 + 1.9, p < 0.01). The sensitivity for the detection of patients with unstable angina was higher in123I-BMIPP than in99mTc-sestamibi (77% vs. 45%, p < 0.01). The site of the decreased123I-BMIPP uptake corresponded to the most stenotic coronary artery lesion in all patients.

Fatty acid metabolic imaging with123I-BMIPP was more sensitive for detecting myocardial ischemia than perfusion imaging with99mTc-sestamibi.123I-BMIPP may be a clue to define the culprit lesion in unstable angina and be helpful to decide the best treatment and guide coronary angioplasty.

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Affiliations

  1. Divisions of Cardiology and Radiology, Ishinomaki Red Cross Hospital, Japan

    Yasuchika Takeishi, Hiroyasu Sukekawa, Haruo Saito, Shozo Nishimura, Takayuki Shibu, Yasuhiko Sasaki & Hitonobu Tomoike

  2. First Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, 990-23, Yamagata, Japan

    Hiroyasu Sukekawa, Haruo Saito, Shozo Nishimura, Takayuki Shibu, Yasuhiko Sasaki & Hitonobu Tomoike

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  1. Yasuchika Takeishi
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  2. Hiroyasu Sukekawa
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  4. Shozo Nishimura
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  5. Takayuki Shibu
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  6. Yasuhiko Sasaki
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Takeishi, Y., Sukekawa, H., Saito, H. et al. Impaired myocardial fatty acid metabolism detected by123I-BMIPP in patients with unstable angina pectoris: Comparison with perfusion imaging by99mTc-sestamibi. Ann Nucl Med 9, 125–130 (1995). https://doi.org/10.1007/BF03165038

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  • DOI: https://doi.org/10.1007/BF03165038

Key words

  • 123I-BMIPP
  • 99mTc-sestamibi
  • unstable angina